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Title In silico technologies in drug target identification and validation / edited by Darryl León, Scott Markel
Published Boca Raton : CRC/Taylor & Francis, [2006]
Online access available from:
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Description 1 online resource (490 pages, 4 unnumbered pages of plates) : illustrations (some color)
Series Drug discovery series ; 6
Drug discovery series ; 6
Contents Pattern matching / Scott Markel and Vinodh N. Rajapakse -- Tools for computational protein annotation and function assignment / Jaume M. Canaves -- The impact of genetic variation on drug discovery and development / Michael R. Barnes -- Mining of gene expression data / Aedin Culhane and Alvis Brazma -- Text mining / Bruce Gomes, William Hayes, and Raf Podowski -- Pathways and networks / Eric Minch and Ivayla Vatcheva -- Molecular interactions: learning from protein complexes / Ana Rojas, David de Juan, and Alfonso Valencia -- In silico siRNA design / Darryl León -- Predicting protein subcellular localization using intelligent systems / Rajesh Nair and Burkhard Rost -- Three-dimensional structures in target discovery and validation / Seán I. O'Donoghue, Robert B. Russell, and Andrea Schafferhans -- Comparative genomics / Viviane Siino, Bruce Pascal, and Christopher Sears -- Pharmacogenomics / Bahram Ghaffarzadeh Kermani -- Target identification and validation using human simulation models / Seth Michelson, Didier Scherrer, and Alex L. Bangs -- Using protein targets for in silico structure-based drug discovery / Tad Hurst -- Database management / Arek Kasprzyk and Damian Smedley -- BioIT hardware configuration / Philip Miller -- BioIT architecture: software architecture for bioinformatics research / Michael Dickson -- Workflows and data pipelines / Michael Peeler -- Ontologies / Robin A. McEntire and Robert Stevens
Summary The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyse potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. "In Silico Technologies in Drug Target Identification and Validation" addresses the challenge of testing a growing number of new potential targets and reviews currently available in silico approaches for identifying and validating these targets. The book emphasizes computational tools, publ
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Drug development -- Computer simulation.
Drug development.
Drug Delivery Systems -- methods.
Chemistry, Pharmaceutical.
Computational Biology.
Form Electronic book
Author León, Darryl.
Markel, Scott.
ISBN 1420015737 (electronic bk.)
9781420015737 (electronic bk.)
(Hardcover ; alk. paper)