| Description |
1 online resource (xxii, 530 pages) : illustrations |
| Contents |
Cover -- Contents -- Preface -- List of Contributors -- I HDL Structure -- 1 Apolipoprotein A-I Structure -- 1.1 Introduction and Perspective -- 1.2 Lipid-Free ApoA-I -- 1.3 The Role of Protein Structure in ApoA-I Function -- 1.4 Full-Length ApoA-I X-Ray Structure -- 1.5 Apolipoprotein A-I Structure 8211; Lipid-Bound State -- 1.6 Structural Studies of ApoA-I on Discoidal Nascent HDL -- 1.7 Hinge Domain -- 1.8 Computer Models -- 1.9 Spherical HDL -- 1.10 Future Directions -- 1.11 Acknowledgments -- 2 Apolipoprotein A-II -- 2.1 Apolipoprotein A-II Structure and Plasma Level Regulation -- 2.2 Pathophysiological Role of ApoA-II -- 2.3 Acknowledgments -- 3 Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking -- 3.1 Introduction -- 3.2 Role of ApoE in Triglyceride-Rich Lipoprotein Metabolism -- 3.3 Role of ApoE in HDL Metabolism -- 3.4 ApoE and Recycling -- 3.5 Summary -- 4 ApoM 8211; A Novel Apolipoprotein with Antiatherogenic Properties -- 4.1 Introduction -- 4.2 Cloning and Characterization of Human ApoM -- 4.3 Gene Location and Amino Acid Sequence of ApoM -- 4.4 Protein Structure of ApoM -- 4.5 Distribution of ApoM in Plasma Lipoproteins -- 4.6 Tissue Distribution and Cellular Expression of ApoM -- 4.7 Putative Functions of ApoM -- 4.8 Regulation of ApoM -- 4.9 Hormonal Regulation of ApoM -- 4.10 Clinical Observations -- 4.11 Conclusions and Perspectives -- II HDL Plasma Metabolic Factors -- 5 ATP Binding Cassette Transporters -- 5.1 The Family of ABC Transporters 8211; General Features -- 5.2 ABC Transporters and Lipid Transport -- 5.3 The ABCA Subfamily and the Handling of Excess Lipids -- 5.4 The ABCG Subfamily and Sterol Trafficking -- 5.5 Acknowledgments -- 6 Reverse Cholesterol Transport 8211; New Roles for Pre946;1-HDL and Lecithin: Cholesterol Acyltransferase -- 6.1 Introduction -- 6.2 Structure and Properties of Pre946;(1)-HDL -- 6.3 Cell Membrane Origin of FC for RCT -- 6.4 Role of ABCA1 in FC Transfer -- 6.5 Mechanism of Lecithin:Cholesterol Acyltransferase (LCAT) -- 6.6 Origins of FC and PL for LCAT Activity -- 6.7 Further Metabolism of LCAT/Pre946;(1)-HDL Complexes -- 6.8 ApoA-1 Recycling and the Production of Pre946;(1)-HDL -- 6.9 Revised Model of RCT -- 7 HDL Remodeling by CETP and SR-BI -- 7.1 Introduction -- 7.2 Atheroprotective Function of HDL -- 7.3 Cholesteryl Ester Transfer Protein (CETP) -- 7.4 Selective Uptake -- 7.5 SR-BI Function and Trafficking in Hepatocytes -- 7.6 Cellular Mechanisms of SR-BI-Mediated Biliary Cholesterol Secretion -- 7.7 Role of CETP in Direct Clearance of HDL-derived CE (Selective Uptake) -- 7.8 Summary -- 8 Human Plasma Phospholipid Transfer Protein (PLTP) 8211; Structural and Functional Features -- 8.1 Introduction -- 8.2 Lipid Transfer Proteins -- 8.3 Phospholipid Transfer Protein (PLTP) -- 8.4 Functions of PLTP -- 8.5 PLTP and Atherosclerosis -- 9 Use of Gene Transfer to Study HDL Remodeling -- 9.1 Introduction -- 9.2 Vectors for Gene Transfer -- 9.3 Roles of Lipases and HDL-Associated Enzymes in HDL Remodeling -- 9.4 Conclusion -- 9.5 Perspective -- 9.6 Acknowledgments -- III HDL Formation, Secretion, Removal -- 10 Regulation of Genes Involved in the Biogenesis and the Remodeling of HDL -- 10.1 Introduction -- 10.2 |
| Summary |
This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention. |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Lipoproteins.
|
|
High density lipoproteins.
|
|
Lipoproteins, HDL
|
| Form |
Electronic book
|
| Author |
Fielding, Christopher J.
|
| ISBN |
9783527625178 |
|
3527625178 |
|
9783527625185 |
|
3527625186 |
|
1282021621 |
|
9781282021624 |
|
