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E-book
Author Neidle, Stephen.

Title Therapeutic applications of quadruplex nucleic acids / Stephen Neidle
Edition First edition
Published London ; Waltham, MA : Elsevier/Academic Press, 2012
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Description 1 online resource (xii, 196 pages) : illustrations
Contents Intro -- history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes -- involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease -- applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands -- chemistry and design -- selectivity and assays -- Quadruplex ligands -- basic biology and assays indirect and direct -- Quadruplex ligands -- pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs -- therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions
Summary New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research
Bibliography Includes bibliographical references and index
Notes Description based on print version record
Subject Quadruplex nucleic acids -- Therapeutic use.
Antineoplastic Agents -- pharmacology.
Antineoplastic Agents -- therapeutic use.
G-Quadruplexes.
Neoplasms -- drug therapy.
Nucleic Acid Conformation.
Telomere -- chemistry.
Form Electronic book
ISBN 0123751381 (electronic bk.)
0123751381 (hbk)
012375139X (electronic bk.)
9780123751386 (electronic bk.)
9780123751386 (hbk)
9780123751393 (electronic bk.)