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Title Advances in DNA sequence specific agents : a research annual. Volume 2 / editor Laurence H. Hurley
Published Greenwich (Connecticut) ; London : Jai Press, 1996
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Description 1 online resource (xi, 347 pages) : illustrations
Series Advances in DNA sequence specific agents ; vol. 2
Contents List of Contributors. Preface Part I: Methods used to evaluate the molecular basis for sequence specificity. Part II: Sequence Specificity of DNA Interactive Drugs
Summary DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of <IT>Advances in DNA Sequence Specific Agents</IT>. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA. This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition
Bibliography Bibliogr. Index
Notes Online version of the print title
Mode of access: World Wide Web
System requirements: Internet connectivity, World Wide Web browser, and Adobe Acrobat
Subject DNA.
Molecular recognition.
Nucleotide sequence.
Form Electronic book
Author Hurley, Laurence H., Ă¢editor
ISBN 1559381663
9781559381666