| Description |
1 online resource |
| Contents |
Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology |
| Summary |
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combi |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record and CIP data provided by publisher |
| Subject |
Combinatorial chemistry -- Technique
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DNA -- Synthesis.
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Gene libraries.
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Combinatorial Chemistry Techniques -- methods
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DNA -- chemical synthesis
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Drug Discovery -- methods
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Gene Library
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Small Molecule Libraries -- chemical synthesis
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MEDICAL -- Pharmacology.
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DNA -- Synthesis
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| Genre/Form |
Methods (Music)
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| Form |
Electronic book
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| Author |
Goodnow, Robert A., Jr., editor.
|
| LC no. |
2013046115 |
| ISBN |
9781118832691 |
|
1118832698 |
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9781118832677 |
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1118832671 |
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9781306642514 |
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1306642515 |
|
