| Description |
1 online resource (xviii, 241 pages) : illustrations |
| Contents |
Chemical modulators of protein misfolding, neurodegeneration and tau -- Targeting the protein quality-control (PQC) machinery -- Targeting proteasomal degradation of soluble, misfolded proteins -- Targeting unselective autophagy of cellular aggregates -- Targeting selective autophagy of insoluble protein aggregates -- Targeting assembly and disassembly of protein aggregates |
| Summary |
This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds Provides discipline-specific chapters that cover medicinal chemistry and clinical applications Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery |
| Notes |
Complemented by: Molecular targets in protein misfolding and neurodegenerative disease / Pierfausto Seneci. [2015] |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Vendor-supplied metadata |
| Subject |
Protein folding.
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Molecular neurobiology.
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Nervous system -- Degeneration.
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Nervous system -- Diseases.
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Tauopathies
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Molecular Targeted Therapy -- methods
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Protein Folding
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Nervous System Diseases
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SCIENCE -- Life Sciences -- Biochemistry.
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Molecular neurobiology
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Nervous system -- Degeneration
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Nervous system -- Diseases
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Protein folding
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| Form |
Electronic book
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| Author |
Complemented by (work): Seneci, Pierfausto, 1960-
Molecular targets in protein misfolding and neurodegenerative disease
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| ISBN |
9780128019597 |
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012801959X |
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