Title Acute exposure guideline levels for selected airborne chemicals. Volume 1 / Subcommittee on Acute Exposure Guideline Levels, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission of Life Sciences, National Research Council

Published Washington, D.C. : National Academy Press, ©2000

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Description 1 online resource (xviii, 201 pages) : illustrations Series The compass series Compass series (Washington, D.C.) Contents Acute Exposure Guideline Levels for Selected Airborne Chemicals -- Copyright -- Preface -- Contents -- Acute Exposure Guideline Levels for Selected Airborne Chemicals -- Introduction -- SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS -- REVIEW OF AEGL REPORTS -- REFERENCES -- Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances -- COMMITTEE MEMBERS -- OAK RIDGE NATIONAL LABORATORY STAFF -- NATIONAL ADVISORY COMMITTEE STAFF -- Appendix -- 1 Aniline1 Acute Exposure Guideline Levels -- SUMMARY 1. INTRODUCTION2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Experimental Studies -- 2.2.2. Epidemiology Studies -- 2.2.3. Accidents -- 2.3. Developmental and Reproductive Effects -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Rats -- 3.1.2. Mice -- 3.2. Nonlethal Toxicity -- 3.2.1. Dogs -- 3.2.2. Rats -- 3.2.3. Mice -- 3.2.4 Guinea pigs -- 3.3. Developmental and Reproductive Effects -- 3.4. Genotoxicity -- 3.5. Carcinogenicity 3.6. Summary4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Susceptible Subpopulations -- 4.4.2. Species Differences -- 4.4.3. Concentration-Exposure Duration Relationship -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Human Data Relevant to AEGL-1 -- 5.2. Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Human Data Relevant to AEGL-2 -- 6.2. Animal Data Relevant to AEGL-2 6.3. Derivation of AEGL-27. DATA ANALYSIS FOR AEGL-3 -- 7.1. Human Data Relevant to AEGL-3 -- 7.2. Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF AEGLS -- 8.1. AEGL Values and Toxicity Endpoints -- 8.2. Comparisons with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- 2 Arsine1 Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.1.1. Case Reports -- 2.2. Nonlethal Toxicity -- 2.2.1. Case Reports 2.2.2. Epidemiologic Studies2.3. Developmental and Reproductive Toxicity -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Nonhuman Primates -- 3.1.2. Dogs -- 3.1.3. Cats -- 3.1.4 Rats -- 3.1.5. Mice -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.2. Rats -- 3.2.3. Mice -- 3.2.4. Hamsters -- 3.3. Developmental/Reproductive Toxicity -- 3.3.1. Rats -- 3.3.2. Mice -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS Bibliography Includes bibliographical references Notes Print version record Subject Gases, Asphyxiating and poisonous. Hazardous substances -- Environmental aspects Hazardous substances -- Health aspects. Chemicals -- Physiological effect. Chemicals -- Health aspects Environmental Exposure -- standards Hazardous Substances -- standards Air Pollutants -- standards Hazardous Substances -- toxicity MEDICAL -- Toxicology. Chemicals -- Health aspects Chemicals -- Physiological effect Gases, Asphyxiating and poisonous Hazardous substances -- Environmental aspects Hazardous substances -- Health aspects Form Electronic book Author National Research Council (U.S.). Subcommittee on Acute Exposure Guideline Levels. ISBN 0309565081 9780309565080

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