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Book Cover
Streaming video
Author Alon, Uri, 1969- speaker

Title Evolutionary tradeoffs and the geometry of gene expression space / Uri Alon
Published London : Henry Stewart Talks, 2014
Online access available from:
Henry Stewart Talks: Biomedical & Life Sciences Lectures    View Resource Record  


Description 1 online resource (1 streaming video file (36 min.) : color, sound)
Series Systems biology, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Systems biology
Contents Contents: Organisms, tissues and molecules often need to perform multiple tasks -- Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff -- We study this using the concept of Pareto optimality from engineering and economics -- Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons -- At the vertices of these polygons are phenotypes that specialize at a single task -- We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
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Subject Bioinformatics.
Biological models.
Evolution (Biology)
Gene expression.
Mathematical optimization.
Molecular biology.
Morphology (Animals)
Beak -- anatomy & histology.
Biological Evolution.
Computational Biology.
Evolution, Molecular.
Fossils -- anatomy & histology.
Gene Expression.
Genes, Bacterial.
Genetic Fitness.
Models, Biological.
Models, Statistical.
Selection, Genetic.
Systems Biology.
Genre/Form Video recordings.
Form Streaming video