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Book Cover
Streaming video
Author Masters, Colin L., speaker

Title Abeta toxicity. Part 1 / Colin L. Masters
Published London : Henry Stewart Talks, 2011
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (54 min.) : color, sound)
Series Alzheimer's disease : neurobiology, pathology and treatment, 2056-452X
Drug discovery and development in the neurosciences, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Alzheimer's disease
Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences
Contents Contents: The amyloid plaque -- Impact of delaying onset of AD -- The amyloidocentric theory of Alzheimer's disease -- Compelling evidence for the Abeta theory of AD -- Delay onset of AD by 5 years -- The best target for a disease-modifying drug -- APP structure and domains -- Iron-export ferroxidase activity of beta-amyloid precursor protein -- Age at onset correlates with Abeta isoforms -- Activation of PS1 -- Abeta amyloid -- The mechanism of neurodegeneration -- Abeta metal binding modes -- Current working model of Abeta toxicity -- Abeta amyloid protein: current model consistent with EXAFS -- Metal-protein attenuating compound (MPAC) with moderate affinity for metals -- Clioquinol (CQ, PBT1) the prototypic MPAC -- PBT2: SAR based on rational drug design -- CQ (PBT1) vs. PBT2 -- Alzheimer's disease Abeta-directed therapeutics in clinical development: drugs and biologics -- Phase II results of Abeta targeting AD modifying drugs
Notes Animated audio-visual presentation with synchronized narration
Title from publisher's website (viewed January 2012)
Mode of access: World Wide Web
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Subject Alzheimer's disease -- Chemotherapy.
Alzheimer's disease -- Pathophysiology.
Alzheimer's disease -- Treatment.
Amyloid beta-protein.
Alzheimer Disease -- drug therapy.
Alzheimer Disease -- physiopathology.
Alzheimer Disease -- therapy.
Amyloid beta-Peptides -- toxicity.
Genre/Form Video recordings.
Form Streaming video
Other Titles Aβ toxicity, Part I Title from title frames
Abeta toxicity, Part I