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Title Accounts in drug discovery : case studies in medicinal chemistry / [edited by] Joel Barrish, Percy Carter, Robert Zahler
Published Cambridge : Royal Society of Chemistry, [2010]
©2011
Online access available from:
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Description 1 online resource
Series RSC Drug Discovery ; 4
RSC drug discovery series ; 4
Contents The discovery of the dipeptidyl peptidase-4 (DPP4) inhibitor Onglyza : from concept to market / Jeffrey A. Robl and Lawrence G. Hamann -- The discovery of Vorapaxar (SCH 530348), a thrombin receptor (protease activated receptor-1) antagonist with potent antiplatelet effects / Samuel Chackalamannil -- The discovery of Piragliatin, a glucokinase activator / Ramakanth Sarabu, Jefferson W. Tilley and Joseph Grimsby -- The discovery of OSI-906, a small-molecule inhibitor of the insulin-like growth factor-1 and insulin receptors / Mark J. Mulvihill and Elizabeth Buck -- The genesis of the antibody conjugate gemtuzumab ozogamicin (Mylotarg®) for acute myeloid leukemia / Philip R. Hamann -- Novel androgen receptor antagonists for the treatment of prostate cancer / Ashvinikumar V. Gavai, William R. Foster, Aaron Balog and Gregory D. Vite -- The discovery of UK-390957 : the challenge of targeting a short half-life, rapid Tmax SSRI / Mark D. Andrews and Donald S. Middleton -- The discovery of the long-acting PDE5 inhibitor PF-489791 for the treatment of pulmonary hypertension / Andrew S. Bell and Michael J. Palmer -- From HTS to market : the discovery and development of maraviroc, a CCR5 antagonist for the treatment of HIV / Chris Barber and David Pryde -- The discovery of GS-9131, an amidate prodrug of a novel nucleoside phosphate HIV reverse transcriptase inhibitor / Richard Mackman -- 2'-F-2'-C-methyl nucleosides and nucleotides for the treatment of hepatitis C virus : from discovery to the clinic / Michael J. Sofia, Phillip A. furman and William T. Symonds -- A case history on the challenges of central nervous system and dual pharmacology drug discovery / Paul V. Fish, Anthony Harrison, Florian Wakenhut and Gavin A. Whitlock -- The discovery of TRPV1 antagonists : turning up the heat / Mark H. Norman -- Uncoupling neuroprotection from immunosuppression : the discovery of ILS-920 / Edmund I. Graziani -- Identification of [alpha] 7 nicotinic acetylcholine receptor agonists for their assessment in improving cognition in schizophrenia / Bruce N. Rogers [and others]
Summary Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening ""hits"" as well as rational, structure-based design. The chapters include ""follow-ons"" and ""next generation"" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal
Notes Online resource; title from title screen (viewed on June 15, 2010)
Subject Drug development -- Case studies.
Pharmaceutical chemistry -- Case studies.
Genre/Form Case studies.
Case studies.
Form Electronic book
Author Barrish, Joel Charles, 1957-
Carter, Percy.
Zahler, Robert
ISBN 1849731985 (electronic bk.)
9781849731980 (electronic bk.)