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Title Prostate cancer : signaling networks, genetics, and new treatment strategies / edited by Richard G. Pestell, Marja T. Nevalainen ; foreword by Michael Milken
Published Totowa, NJ : Humana Press, [2008]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource (xv, 455 pages) : illustrations
Series Current clinical oncology
Current clinical oncology.
Contents Histopathology and molecular biology of prostate atrophy: a lesion associated with inflammation, prostate intraepithelial neoplasia, and prostate cancer -- Epigenetic gene silencing in prostate cancer -- Inherited genetic changes in prostate cancer -- Prostate molecular oncogenesis: gene deletions and somatic mutations -- Somatic genetic changes in prostate cancer: androgen receptor alterations -- Androgen receptor in prostate cancer progression -- Epigenetic modification and acetylation of androgen receptor regulate prostate cellular growth -- Estrogen receptor a [alpha] and b [beta] in the regulation of normal and malignant prostate epithelium -- Estrogen action in normal prostate epithelium and in prostate cancer -- Hypoxia-inducible factor 1 in the angiogenesis of prostate cancer -- Signal transduction by the Ras-MAP kinase pathway in prostate cancer progression -- Transcription factors STAT5 and STAT3: survival factors for prostate cancer cells -- Role of P13K-Akt and PTEN in the growth and progression of prostate cancer -- New perspectives in prediction of clinical outcome of prostate cancer; TMPRSS2-ETS gene fusion in prostate cancer -- New directions in radiation therapy of prostate cancer: brachytherapy and intensity-modulated radiation therapy -- The current knowledge of hormonal therapy in the treatment of prostate cancer -- Advances in surgical intervention of prostate cancer: comparison of the benefits and pitfalls of retropubic, perineal, and laparoscopic radical prostatectormy -- Targeted therapy trials for prostate cancer -- New perspectives on chemotherapy in prostate cancer -- Concluding remarks: the future of prostate cancer
Summary Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. In, "Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies", the authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer research, such as laparoscopic radical prostatectomy, and offers a critical evaluation and discussion of opportunities for development of novel therapies for prostate cancer. Clinical trials that have not been covered or evaluated in any other books currently available are also discussed. Invaluable to physicians and researchers, "Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies" provides a comprehensive translational resource as well as an important source of information for prostate cancer patients
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cellular signal transduction.
Prostate -- Cancer -- Genetic aspects.
Prostate -- Cancer -- Treatment.
Prostate -- Cancer.
Prostatic Neoplasms -- genetics.
Prostatic Neoplasms -- physiopathology.
Prostatic Neoplasms -- therapy.
Form Electronic book
Author Nevalainen, Marja T.
Pestell, Richard G.
LC no. 2007941659
ISBN 1588297411 (cloth ; alk. paper)
9781588297419 (cloth ; alk. paper)