| Description |
1 online resource (xiii, 279 pages) : illustrations (some color) |
| Contents |
A Brief History of PNH -- Genetics of PNH -- Hemolysis in PNH -- Thrombotic Complications in PNH -- Bone Marrow Failure in PNH -- Animal Models of PNH -- The Function of GPI-Anchored Proteins -- GPI in Lower Animals -- Synthesis of the GPI Anchor -- Functional and Structural Organization of GPI-Anchored Proteins in Cellular Membranes -- Structure and Function of GPI-Specific Phospholipases |
| Summary |
Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins |
| Analysis |
hemoglobinurie |
|
haemoglobinuria |
|
Human Pathology |
|
Humane pathologie |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Paroxysmal hemoglobinuria.
|
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Phosphoinositides.
|
|
Glycoproteins.
|
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Membrane proteins.
|
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Cellular signal transduction.
|
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Hemoglobinuria, Paroxysmal
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Phosphatidylinositols
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Membrane Proteins
|
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Signal Transduction
|
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Glycoproteins
|
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Glycosylphosphatidylinositols
|
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MEDICAL -- Hematology.
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Cellular signal transduction
|
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Glycoproteins
|
|
Membrane proteins
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Paroxysmal hemoglobinuria
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Phosphoinositides
|
| Form |
Electronic book
|
| Author |
Young, Neal S.
|
|
Moss, Joel.
|
| ISBN |
9780127729404 |
|
0127729402 |
|
9780080492094 |
|
0080492096 |
|
1281005622 |
|
9781281005625 |
|
9786611005627 |
|
6611005625 |
|
