| Description |
1 online resource (xv, 326 pages) : illustrations |
| Contents |
Cover -- Foreword -- Preface -- Acknowledgements -- Contributors of Electron Micrographs -- Table of Contents -- The Cell -- Introduction: Structural organisation of a mammalian cell -- The Nucleus -- Architecture of the cell nucleus -- Cytochemical detection of ribonucleoproteins -- Nuclear lamina -- Detection of sites of DNA replication and of interphase chromosome domains -- Nucleolus -- Changes of the nucleolar architecture -- Detection of sites of RNA synthesis -- Nuclear pore complexes -- Nuclear pore complexes: Structural changes as monitored by time-lapse atomic force microscopy -- Mitosis and cell division -- Apoptosis -- Viral inclusions -- The Cytoplasm: The Secretory System -- Secretory pathway of pancreatic acinar cells -- Ribosomes, rough endoplasmic reticulum -- Nuclear envelope and rough endoplasmic reticulum -- Rough endoplasmic reticulum: Site of protein translocation and initiation of protein N-glycosylation -- Oligosaccharide trimming, reglucosylation, and protein quality control in the rough endoplasmic reticulum -- Rough endoplasmic reticulum: Storage site of aggregates of misfolded glycoproteins -- Russell bodies and aggresomes represent different types of protein inclusion bodies -- Smooth endoplasmic reticulum -- Proliferation of the smooth endoplasmic reticulum -- Pre-Golgi intermediates -- Pre-Golgi intermediates: Oligosaccharide trimming and protein quality control -- Golgi apparatus: A main crossroads along secretory pathways -- Protein secretion visualised by immunoelectron microscopy -- Protein N-glycosylation: Oligosaccharide trimming in the Golgi apparatus and pre-Golgi intermediates -- Golgi apparatus: Site of maturation of asparagine-linked oligosaccharides -- Cell-type-related variations in the topography of Golgi apparatus glycosylation reactions -- Cell-type-related differences in oligosaccharide structure -- Topography of biosynthesis of serine/threonine-linked oligosaccharides -- Golgi apparatus and TGN ... Secretion and endocytosis -- Golgi apparatus, TGN and trans-Golgi-ER -- Golgi apparatus, TGN and trans-Golgi-ER: Tilt series -- Brefeldin A-induced disassembly of the Golgi apparatus -- Brefeldin A-treatment: Tubulation of Golgi apparatus and endosomes -- Brefeldin A-treatment: Effect on retrograde transport of internalised WGA -- Brefeldin A-treatment: Transitional ER-elements and pre-Golgi intermediates -- Heat shock response of the Golgi apparatus -- Changes of the Golgi apparatus upon ATP-depletion and ATP-replenishment -- Secretory granules -- Secretory granule types -- The Cytoplasm: The Endocytic System -- Receptor-mediated endocytosis via clathrin-coated vesicles and virus endocytosis -- Endosomes and endocytic pathways -- Endocytic trans-Golgi network and retrograde traffic into the Golgi apparatus -- Tubular pericentriolar endosomes -- Langerhans cells and Birbeck granules: Antigen presenting dendritic cells of the epidermis -- Caveolae -- Fluid phase endocytosis and phagocytosis -- The Cytoplasm: Lysosomes and Lysosomal Disorders -- Lysosomes -- Lysosomes: Localisation of acid phosphatase, LAMP and polylactosamine -- I-cell disease -- Gaucher's disease -- Fabry's disease -- GM2 gangliosidoses -- Farber's disease -- Wolman's disease -- tidt |
| Summary |
The period between 1950 and 1980 were the golden It also provides unique insights into how pathological years of transmission electron microscopy and pro- processes affect cell organization. duced a plethora of new information on the structure of This information is vital to current work in which cells that was coupled to and followed by biochemical the emphasis is on integrating approaches from p- and functional studies. TEM was king and each micro- teomics, molecular biology, molecular imaging and graph of a new object produced new information that physiology, and pathology to understand cell functions led to new insights on cell and tissue organization and and derangements in disease. In this current era, there is their functions. The quality of data represented by the a growing tendency to substitute modern light mic- images of cells and tissues had been perfected to a very scopic techniques for electron microscopy because it is high level by the great microscopists of the era including less technically demanding and is more readily available Palade, Porter, Fawcett, Sjostrand, Rhodin and many to researchers. This atlas reminds us that the infor- others. At present, the images that we see in leading tion obtained by electron microscopy is invaluable and journals for the most part do not reach the same techni- has no substitute |
| Analysis |
biochemie |
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biochemistry |
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microbiologie |
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microbiology |
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geneeskunde |
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medicine |
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pathologie |
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pathology |
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biomedische wetenschappen |
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biomedicine |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
OhioLINK electronic book center |
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SpringerLink |
| Subject |
Ultrastructure (Biology) -- Atlases
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Electron microscopy.
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Cells -- ultrastructure
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Microscopy, Electron
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Organelles -- ultrastructure
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Tissues -- ultrastructure
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electron microscopy.
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SCIENCE -- Life Sciences -- Cell Biology.
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Cells -- ultrastructure.
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Microscopy, Electron.
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Organelles -- ultrastructure.
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Tissues -- ultrastructure.
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Ultrastructure (Biology)
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Biomédecine.
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Sciences de la vie.
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Electron microscopy
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Ultrastructure (Biology)
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| Genre/Form |
atlases.
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Scientific atlases
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Atlases
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Atlases.
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Atlas.
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| Form |
Electronic book
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| Author |
Roth, Jürgen
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| ISBN |
9783211263921 |
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3211263926 |
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3211835644 |
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9783211835647 |
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6610234485 |
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9786610234486 |
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