| Description |
1 online resource (xx, 404 pages) : illustrations |
| Contents |
Viral Therapy of Cancer; Contents; Foreword; Preface; Contributors; 1 Adenoviruses; 2 Application of HSV-1 vectors to the treatment of cancer; 3 Adeno-associated virus; 4 Retroviruses; 5 Lentiviral vectors for cancer gene therapy; 6 Poxviruses as immunomodulatory cancer therapeutics; 7 Oncolytic herpes simplex viruses; 8 Selective tumour cell cytotoxicity by reoviridae preclinical evidence and clinical trial results; 9 Oncolytic vaccinia; 10 Newcastle Disease virus: a promising vector for viral therapy of cancer; 11 Vesicular stomatitis virus; 12 Measles as an oncolytic virus; 13 Alphaviruses |
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14 Tumour-suppressor gene therapy15 RNA interference and dominant negative approaches; 16 Gene-directed enzyme prodrug therapy; 17 Immunomodulatory gene therapy; 18 Antiangiogenic gene delivery; 19 Radiosensitization in viral gene therapy; 20 Radioisotope delivery; 21 Radioprotective gene therapy: current status and future goals; 22 Chemoprotective gene delivery; Index |
| Summary |
In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present t |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Cancer -- Treatment.
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Viruses -- Therapeutic use.
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Genetic Therapy.
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Neoplasms -- therapy.
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Oncolytic Virotherapy.
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Oncolytic Viruses.
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| Form |
Electronic book
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| Author |
Harrington, Kevin J., 1958-
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Pandha, Hardev.
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Vile, Richard G.
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Wiley InterScience (Online service)
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| ISBN |
047098578X (electronic bk.) |
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0470985798 |
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9780470985786 (electronic bk.) |
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9780470985793 |
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(cloth ; alk. paper) |
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(cloth ; alk. paper) |
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