| Description |
1 online resource |
| Contents |
Cover -- Title Page -- Copyright Page -- Dedication -- Preface -- Acknowledgments -- The Author -- Table of Contents -- Chapter 1: Candidate Substances, Research Background, and Biological Roles -- I. What is an Endogenous Sleep Substance? -- II. Origin of Humoral Theories of Sleep Regulation -- A. Ancient Theories -- B. Early Experimental Attempts -- III. Pioneering Approaches with Modem Techniques -- A. Sleep Substances from Sleeping Animals -- B. Sleep Substances from Sleep-Deprived Animals -- 1. Total Sleep Deprivation -- 2. Selective Sleep Deprivation |
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5. 1-h Assay in Rats -- B. Standardized Long-Term Sleep Bioassay Techniques -- 1. 4-d Assay for SPS in Rats -- 2. 11-d Assay for Gastrointestinal Hormones in Rats -- 3. 2-d Assay for Neuropeptides in Rats -- References -- Chapter 3: Delta-Sleep-Inducing Peptide and Its Derivatives -- I. Sleep-Promoting Properties -- A. Induction of Delta Sleep -- 1. Experiments in Rabbits -- 2. Experiments in Cats -- 3. Experiments in Rats -- 4. Experiments in Other Animals -- 5. Experiments in Healthy Humans -- B. Induction of Paradoxical Sleep -- C. No Somnogenic Activity or Enhancement of Wakefulness |
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D. Circadian Variations in Effectiveness -- II. Chemical and Biochemical Aspects -- A. Conformation of DSIP and Its Synthetic Analogs -- B. Other Active Analogs -- C. Phosphorylated DSIP (P-DSIP) -- D. Degradation -- E. Receptors -- III. Bodily Distributions -- A. Brain and Peripheral Organs -- B. Body Fluids -- C. Circadian Rhythm of Plasma DSIP -- D. Blood-Brain Barrier -- IV. Extra-Sleep Effects -- A. Multiple Functions of DSIP -- B. Effects on Temperature -- C. Blood Pressure and Anxiolytic Action -- D. Neuronal Firing Activity -- E. Locomotor Activity -- V. Interactions with Other Factors |
| Summary |
All aspects of sleep sciences are included in this excellent resource text, with special reference to sleep substances and sleep modulators. The historical development of the theories of sleep are reviewed in conjunction with the technical problems. All candidate substances are overviewed as to their sites of presence, chemical nature, bioassay techniques, physiological and pharmacological effects. On the basis of a standardized methodology developed by the author, sleep-modulatory characteristics of some substances are compared and evaluated in quantitative terms. The sleep regulatory mechanisms, which are composed of complex neurohumoral subsystems, are analyzed from the results of recent neurophysiological and neuroendocrinological experiments. Furthermore, an evolutionary aspect of sleep substances is taken into consideration.Chapters Highlight:Techniques for isolation and evaluationProstaglandinsParadoxical sleep factorsSleep-promoting substances and nucleosides |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Neuropeptides -- Physiological effect
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Sleep substances.
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Sleep -- Physiological aspects.
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Neuropeptides.
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Sleep.
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Neuropeptides -- Physiological aspects
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Neuropeptides
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Neuropeptides -- metabolism
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Sleep
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Sleep -- physiology
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MEDICAL / Pharmacology
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SCIENCE / Life Sciences / General
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Sleep
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Neuropeptides
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Neuropeptides -- Physiological effect
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Sleep substances
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Sleep -- Physiological aspects
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| Form |
Electronic book
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| LC no. |
88019049 |
| ISBN |
9781000141580 |
|
1000141586 |
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9781003068228 (electronic bk) |
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1003068227 (electronic bk) |
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9781000120257 |
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1000120252 |
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9781000103083 |
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1000103080 |
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