| Description |
1 online resource (xxix, 1971 pages) |
| Contents |
List of contributors -- Preface -- Acknowledgments -- Part 1: INTRODUCTION -- 1 Cardinal manifestations of cancer -- 2 Biological hallmarks of cancer -- Part 2: TUMOR BIOLOGY -- 3 Molecular biology, genomics, proteomics, and mouse models of human cancer -- 4 Oncogenes -- 5 Tumor suppressor genes -- 6 Epigenetic contributions to human cancer -- 7 Cancer genomics and evolution -- 8 Chromosomal aberrations in cancer -- 9 MicroRNA expression in cancer -- 10 Aberrant signaling pathways in cancer -- 11 Differentiation therapy -- 12 Cancer stem cells -- 13 Cancer and cell death -- 14 Cancer cell immortality: targeting telomerase -- 15 Cancer metabolism -- 16 Modeling therapy of late or early-stage metastatic disease in mice -- 17 Tumor angiogenesis -- Part 3: QUANTITATIVE ONCOLOGY -- 18 Cancer bioinformatics -- 19 Systems biology and genomics -- 20 Statistical innovations in cancer research -- 21 Biomarker-based clinical trial design in the era of genomic medicine -- 22 Clinical informatics -- Part 4: CARCINOGENESIS -- 23 Chemical carcinogenesis -- 24 Endocrine and genetic bases of hormone-related cancers -- 25 Ionizing radiation -- 26 Ultraviolet radiation carcinogenesis -- 27 Inflammation and cancer -- 28 RNA tumor viruses -- 29 Herpesviruses -- 30 Papillomaviruses and cervical neoplasia -- 31 Hepatitis viruses and hepatoma -- 32 Parasites -- Part 5: EPIDEMIOLOGY, PREVENTION AND DETECTION -- 33 The burden of cancer worldwide: current and future perspectives -- 34 Cancer epidemiology -- 35 Behavioral approaches to cancer prevention -- 36 Diet and nutrition in the etiology and prevention of cancer -- 37 Chemoprevention of cancer -- 38 Cancer screening and early detection -- Part 6: CLINICAL DISCIPLINES -- 39 Nexgen pathology: predicting clinical course and targeting disease causation -- 40 Molecular diagnostics in cancer -- 41 Principles of imaging -- 42 Interventional radiology for the cancer patient -- 43 Principles of surgical oncology -- 44 Principles of radiation oncology -- 45 Principles of medical oncology -- 46 Palliative care and pain management -- 47 Principles of psycho-oncology -- 48 Principles of cancer rehabilitation medicine -- 49 Integrative oncology in cancer care -- 50 Health services research -- Part 7: INDIVIDUALIZED TREATMENT -- 51 Personalized medicine in oncology drug development -- Part 8: CHEMOTHERAPY -- 52 Preclinical and early clinical development of chemotherapeutic drugs, mechanism-based agents and biologics -- 53 Tumor growth kinetics -- 54 Principles of dose, schedule, and combination therapy -- 55 Pharmacology -- 56 Folate antagonists -- 57 Pyrimidine and purine antimetabolites -- 58 Alkylating agents and platinum antitumor compounds -- 59 DNA topoisomerase targeting drugs -- 60 Agents targeting microtubules and mitotic processes -- 61 Endocrine therapy for hormone receptor-positive breast cancer -- 62 Drug resistance and its clinical circumvention -- Part 9: BIOLOGICAL AND GENE THERAPY -- 63 Cytokines, interferons, and hematopoietic growth factors -- 64 Monoclonal serotherapy -- 65 Vaccines and immunostimulants -- 66 Cell-based cancer immunotherapy -- 67 Cancer immunotherapy -- 68 Cancer gene therapy -- 69 Cancer nanotechnology -- 70 Hematopoietic cell transplantation -- Part 10: SPECIAL POPULATIONS -- 71 Principles of pediatric oncology -- 72 Cancer and pregnancy -- 73 Cancer and aging -- 74 Disparities in cancer care -- 75 Neoplasms in acquired immunodeficiency syndrome -- 76 Cancer survivorship: new challenge in cancer medicine -- Part 11: DISEASE SITES -- 77 Primary and metastatic neoplasms of the brain in adults --78 Neoplasms of the eye -- 79 Neoplasms of the endocrine glands: pituitary neoplasms -- 80 Neoplasms of the thyroid -- 81 Neoplasms of the adrenal cortex -- 82 Tumors of the diffuse neuroendocrine and gastroenteropancreatic system -- 83 Neoplasms of the head and neck -- 84 Cancer of the lung -- 85 Malignant pleural mesothelioma -- 86 Thymomas and thymic tumors -- 87 Tumors of the heart and great vessels -- 88 Primary germ cell tumors of the thorax -- 89 Neoplasms of the esophagus -- 90 Carcinoma of the stomach -- 91 Primary neoplasms of the liver -- 92 Gallbladder and bile duct cancer -- 93 Neoplasms of the exocrine pancreas -- 94 Neoplasms of the small intestine, vermiform appendix, and peritoneum, and carcinoma of the colon and rectum -- 95 Neoplasms of the anus -- 96 Renal cell carcinoma -- 97 Urothelial cancer -- 98 Neoplasms of the prostate -- 99 Tumors of the penis and the urethra -- 100 Testis cancer -- 101 Neoplasms of the vulva and vagina -- 102 Neoplasms of the cervix -- 103 Endometrial cancer -- 104 Epithelial ovarian, fallopian tube, and peritoneal cancer -- 105 Nonepithelial ovarian malignancies -- 106 Molar pregnancy and gestational trophoblastic neoplasia -- 107 Gynecologic sarcomas -- 108 Neoplasms of the breast -- 109 Malignant melanoma -- 110 Other skin cancers -- 111 Bone tumors -- 112 Soft tissue sarcomas -- 113 The myelodysplastic syndrome -- 114 Acute myeloid leukemia in adults: mast cell leukemia and other mast cell neoplasms -- 115 Chronic myeloid leukemia -- 116 Acute lymphoblastic leukemia -- 117 Chronic lymphocytic leukemia -- 118 Hodgkin lymphoma -- 119 Non-Hodgkin's lymphoma -- 120 Mycosis fungoides and Sézary syndrome -- 121 Plasma cell tumors -- 122 Myeloproliferative neoplasms: essential thrombocythemia, primary myelofibrosis, and polycythemia vera -- Part 12: MANAGEMENT OF CANCER COMPLICATIONS -- 123 Neoplasms of unknown primary site -- 124 Anorexia and cachexia -- 125 Antiemetic therapy -- 126 Neurologic complications of cancer -- 127 Dermatologic complications of cancer chemotherapy -- 128 Skeletal complications -- 129 Hematologic complications and blood bank support -- 130 Coagulopathic complications of cancer patients -- 131 Urologic complications -- 132 Cardiac complications -- 133 Respiratory complications -- 134 Gastrointestinal and hepatic complications in cancer patients -- 135 Oral complications of cancer and their treatment -- 136 Gonadal complications -- 137 Sexual dysfunction -- 138 Endocrine complications and paraneoplastic syndromes -- 139 Infections in patients with cancer -- 140 Oncologic emergencies -- Part 13: THE FUTURE OF ONCOLOGY -- 141 A vision for twenty-first century healthcare -- Index |
| Summary |
"The original reference resource for medical oncologists, radiation oncologists, internists, and allied specialties involved in the treatment of cancer patients, Holland-Frei Cancer Medicine covers the ever-expanding field of current cancer science and clinical oncology practice. In this new ninth edition an outstanding editorial team from world-renowned medical centers continue to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging, and therapy. Holland-Frei Cancer Medicine, Ninth Edition, brings scientific principles to clinical practice and is a testament to the ethos that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. This ninth edition features hundreds of full color illustrations, photographs, tables, graphs and algorithms that enhance understanding of complex topics and make this text an invaluable clinical tool. Over 15 brand new chapters covering the latest advances, including chapters on Cancer Metabolism, Bioinformatics, Biomarker Based Clinical Trial Design, Health Services Research and Survivorship bring this comprehensive resource up-to-date. Each chapter contains overview boxes, select references and other pedagogic features, designed to make the content easy to access and absorb"--Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Preceded by Holland-Frei cancer medicine 8, 2010 |
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Print version record |
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Online resource; title from digital title page (viewed on April 06, 2017) |
| Subject |
Cancer -- Diagnosis.
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Cancer -- Treatment.
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Neoplasms
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cancer -- Diagnosis
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Cancer -- Treatment
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| Form |
Electronic book
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| Author |
Bast, Robert C., Jr. (Robert Clinton), 1943- editor.
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| LC no. |
2016018267 |
| ISBN |
9781119000846 |
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111900084X |
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9781119000822 |
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1119000823 |
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