| Description |
1 online resource |
| Contents |
pt. 1. Systems Biology in Cancer. Systems Biology Approach to Metabolomics in Cancer Studies / Mariano Bizzarri, Simona Dinicola and Cesare Manetti -- System Biology Approach to Study Cancer Related Pathways / Yike Guo and Xian Yang -- Modeling Oncogenic Signaling Networks from Gene Expression Dynamics / Aliccia Bollig-Fischer -- An Integrated Systems Approach to the Study of Pancreatic Cancer / Emanuela Gadaleta, Rosalind J. Cutts, Ajanthah Sangaralingam, Nicholas R. Lemoine and Claude Chelala -- Protein Microarray: An Ideal Platform for Systems Biology / Zong-Xiu Wang, Rui-Ping Deng, Shu-Juan Guo, Ji-Bin Zhang and Sheng-Ce Tao -- Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance / Sara Chiblak, Fevzi Demircioglu, Azadeh Fahim Golestaneh and Amir Abdollahi |
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pt. 2. System Approaches to Understanding Cancer. Understanding Cancer Progression Using Protein Interaction Networks / Emre Guney, Rebeca Sanz-Pamplona, Angels Sierra and Baldo Oliva -- Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach / M.M. Quinas-Guerra, T.M. Ribeiro-Rodrigues, Juan Carlos Rodríguez-Manzaneque and Rui D.M. Travasso -- Applications of Network Bioinformatics to Cancer Angiogenesis / Corban G. Rivera, Liang-Hui Chu, Joel S. Bader and Aleksander S. Popel |
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pt. 3. Systems and Network Biology in Decoding miRNA Complexity. Human MicroRNA Targetome Indicates a Specialized Role of MicroRNAs in Regulation of Oncogenesis / Jun-ichi Satoh -- Novel and Alternative Bioinformatics Approaches to Understand miRNA-mRNA Interactome in Cancer Research / Xiaohong Li, Carolyn M. Klinge and Susmita Datta -- Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network / Xia Li, Juan Xu and Yongsheng Li |
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pt. 4. Network Modeling in Cancer Drug Discovery and Clinical Trials. Development and Clinical Implementation of Reverse Phase Protein Microarrays for Protein Network Activation Mapping: Personalized Cancer Therapy / Mariaelena Pierobon, Julie Wulfkuhle, Lance A. Liotta and Emanuel F. Petricoin III -- The Principle of Rational Design of Drug Combination and Personalized Therapy Based on Network Pharmacology / Jianghui Xiong, Simon Rayner, Fengji Liang and Yinghui Li -- Relevance of Network Hierarchy in Cancer Drug-Target Selection / Aritro Nath and Christina Chan -- Computational Infrastructures for Large-Scale Data Access and Analysis in Post-Genomic Clinical Trials / Manolis Tsiknakis -- Network Pharmacology: An Emerging Area in Anti-Cancer Drug Discovery / Asfar S. Azmi, Frances W.J. Beck, Bin Bao, Fazlul H. Sarkar and Ramzi M. Mohammad |
| Summary |
""Systems Biology in Cancer Research and Drug Discovery"" provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology in understanding aberrant signaling in cancer; in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways; in unwinding microRNAs complexity; and in anticancer drug discovery and in clinical trial design. This book revie |
| Analysis |
Medicine |
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Oncology |
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Bioinformatics |
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Biological models |
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Biomedicine |
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Cancer Research |
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Systems Biology |
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systeembiologie |
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biomedische wetenschappen |
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neoplasms |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| In |
Springer eBooks |
| Subject |
Cancer -- Research.
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Systems biology.
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Drug development.
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Drugs -- Design.
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Pharmacy -- Technological innovations
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Research.
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Neoplasms
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Systems Biology -- methods
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Drug Discovery
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Research
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Systems Biology
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Drug Design
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research (function)
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HEALTH & FITNESS -- Diseases -- Cancer.
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MEDICAL -- Oncology.
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Research
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Cancer -- Research
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Drug development
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Drugs -- Design
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Pharmacy -- Technological innovations
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Systems biology
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| Form |
Electronic book
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| Author |
Azmi, Asfar S
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| ISBN |
9789400748194 |
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9400748191 |
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9400748183 |
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9789400748187 |
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9400794355 |
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9789400794351 |
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