Title Biomolecular feedback systems / Domitilla Del Vecchio and Richard M. Murray

Published Princeton, New Jersey ; Oxford, England : Princeton University Press, 2015 ©2015

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Description 1 online resource (286 pages) : illustrations Contents Frontmatter -- Contents -- Preface -- Chapter 1. Introductory Concepts -- Chapter 2. Dynamic Modeling of Core Processes -- Chapter 3. Analysis of Dynamic Behavior -- Chapter 4. Stochastic Modeling and Analysis -- Chapter 5. Biological Circuit Components -- Chapter 6. Interconnecting Components -- Chapter 7. Design Tradeoffs -- Bibliography -- Index Summary This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources. Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems. Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu Bibliography Includes bibliographical references and index Notes Print version record Subject Biological control systems. Systems biology. MEDICAL -- Physiology. SCIENCE -- Life Sciences -- Human Anatomy & Physiology. TECHNOLOGY & ENGINEERING -- Biomedical. Biological control systems Systems biology Form Electronic book Author Murray, Richard M., author ISBN 9781400850501 1400850509 0691161534 9780691161532

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