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Title Congenital and acquired bone marrow failure / edited by M.D. Aljurf, E. Gluckman, C. Dufour
Published London : Academic Press, 2017
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Description 1 online resource (290)
Contents Cover; Title page; Copyright page; Contents; List of Contributors; Introduction; Chapter 1 -- Epidemiology of Acquired Bone Marrow Failure; Introduction; Incidence of AA in different geographical regions and race; Age and gender related demographics of AA; Posthepatitis AA and AA occurring after viral infections; AA and association with toxins/drugs; AA and association with HLA genes; AA and autoimmune disorders; AA during pregnancy; AA postvaccination; Problems with epidemiological studies in AA and future strategies; References; Chapter 2 -- Pathophysiology of Acquired Bone Marrow Failure
AA and HLA-DR TypingAA and LGL; Diagnostic of AA in the Elderly; Defining Severity of AA; Defining Response After Treatment; Future challenges in the diagnostics of AA; Acknowledgment; References; Chapter 4 -- Acquired Overlap Bone Marrow Failure Disorders; Introduction; Hypoplastic MDS; Single lineage cytopenias (pure red cell aplasia or immune thrombocytopenia); T cell large granular lymphocytes; Paroxysmal nocturnal hemoglobinuria; Congenital marrow failure undiagnosed; Conclusions; References; Chapter 5 -- Supportive Care in Aplastic Anemia; Introduction
Introduction: Evidence and Inferences from the ClinicPathophysiology; Hematopoiesis in AA; Immune Mechanisms in AA; Clinical Data; T Cells and Cytokines; HLA and Cytokine Gene Polymorphisms; Immune Escape Clones (PNH, 6pLOH); STAT3 Mutant Clones; Innate Immunity; microRNAs; Autoantibodies; Immune-Mediated BM Failure Mouse Models; Mouse Models of Chemical and Drug Hematopoietic Toxicity; Genetic Risk Factors in AA; Clonal Evolution in AA; Treatments for AA; BMT With Matched Sibling Donors; BMT From Alternative Donors; Experimental HSCT; IST; Eltrombopag; Supportive Care; Conclusions
Prevention of infections by general medical management of aplastic anemia patientsProtective Environment; Protective Isolation; Special Low Bacterial Diet; Individual Hygiene Rules; Prevention of infections by antibiotic/antimycotic/antiviral prophylaxis; Antimycotic Prophylaxis; Antibiotic Prophylaxis; Antiviral Prophylaxis; Vaccination; Hematopoietic growth factors as prophylaxis of infections or in combination with immunosuppression to improve quality of re ... ; Treatment of infections; Granulocyte Transfusions; Transfusion therapy; Iron chelation therapy; Physical exercise
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Bone marrow -- Diseases.
Bone Marrow Diseases.
Form Electronic book
Author Aljurf, M. D. (Mahmoud Deeb)
Dufour, C. (Carlo)
Gluckman, Eliane.
ISBN 0128041757 (ebk)
9780128041758