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Title MACPF/CDC proteins-- agents of defence, attack and invasion / Gregor Anderluh, Robert Gilbert, editors
Published Dordrecht : Springer, 2014
Online access available from:
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Description 1 online resource
Series Subcellular biochemistry ; volume 80
Sub-cellular biochemistry ; v. 80
Contents Part I: Overview of MACPF/CDCs -- Introduction: Brief Historical Overview -- Distribution of MACPF/CDC proteins -- Evolution of the Complement System -- Part II: Structures of MACPF/CDCs -- Structural Features of Cholesterol Dependent Cytolysins and Comparison to other MACPF-domain containing proteins -- Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins -- Structural Biology of the Membrane Attack Complex -- Part III: Functional aspect -- Membrane Interactions and Cellular Effects of MACPF/CDC Proteins -- The Biology of Pneumolysin -- Multifaceted Activity of Listeriolysin O, the Cholesterol-Dependent Cytolysin of Listeria monocytogenes -- Perforin -- a Key Pore-Forming Protein for Immune Control of Viruses and Cancer -- Perforin and Human Diseases -- The role of MACPF Proteins in the Biology of Malaria and other Apicomplexan Parasites -- Chlamydial MACPF Protein CT153 -- Fungal MACPF-Like Proteins and Aegerolysins: Bi-Component Pore-Forming Proteins? -- Fluorescence Imaging of MACPF/CDC Proteins: New Techniques and Their Application
Summary This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of developm
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (Ebsco; viewed on May 15, 2014)
Subject Proteins.
Proteins -- Biotechnology.
Cell membranes.
Complement Membrane Attack Complex -- immunology.
Perforin -- immunology.
Form Electronic book
Author Anderluh, Gregor, 1969- editor
Gilbert, Robert (Robert J. C.), editor
ISBN 9789401788816 (electronic bk.)
9401788812 (electronic bk.)
9401788804 (print)
9789401788809 (print)