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Title Human interphase chromosomes : biomedical aspects / Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov, editors
Published New York, NY : Springer, [2013]
©2013
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Contents Introduction to Interphase Molecular Cytogenetics / Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov -- Interphase Chromosome Behavior in Normal and Diseased Cells / Gemma Bourne, Catherine Moir, Ural Bikkul, Mai Hassan Ahmed -- Nuclear Architecture, Chromosome Aberrations, and Genetic Damage / Gustavo A. Folle, María Vittoria Di Tomaso -- Interphase Chromosomes of the Human Brain: The Biological and Clinical Meaning of Neural Aneuploidy / Ivan Y. Iourov, Svetlana G. Vorsanova, Yuri B. Yurov -- Differentiating Chromosome Fragmentation and Premature Chromosome Condensation / Joshua B. Stevens, Henry H.Q. Heng -- Chromosomes and Nuclear Organization in ICF Syndrome / Emanuela V. Volpi -- Interphase Cytogenetics at the Earliest Stages of Human Development / Darren K. Griffin, Gothami Fonseka, Helen G. Tempest -- Organization of Chromosomes in Human Sperm Nucleus / Olga S. Mudrak, Liudmila V. Solovjeva, Vadim O. Chagin -- Interphase Chromosome-Specific Multicolor Banding / Ivan Y. Iourov, Thomas Liehr, Svetlana G. Vorsanova -- Chromosome Architecture Studied by High-Resolution FISH Banding in Three Dimensionally Preserved Human Interphase Nuclei / Thomas Liehr, Hasmik Mkrtchyan, Marina Manvelyan -- Technological Solutions in Human Interphase Cytogenetics / Svetlana G. Vorsanova, Yuri B. Yurov, Ivan Y. Iourov
Summary The beginning of interphase cytogenetics can be attributed to significant advances in human molecular genetics and cytogenetics. Owing to experimental and theoretical research at the interface between cellular and molecular levels of chromosomal organization and function, high-resolution techniques for chromosomal analysis (molecular cytogenetic techniques) have become available. Molecular cytogenetics is a branch of biomedical sciences that explores chromosomes at molecular and single-cell resolutions at all stages of the cell cycle. It also comprises the techniques that operate with either the entire genome or specific DNA sequences to analyze genomic structural and functional variations at chromosomal level. In postgenomic era, molecular cytogenetics has appreciably transformed and has given rise to a new field of genomics, called cytogenomics. As a result, new opportunities have emerged for analysis of human interphase chromosomes in almost all cell types and states at unprecedented resolution. In Human Interphase Chromosomes, the editors have provided an overview of current developments in the study of human interphase chromosomes with a special attention to available molecular cytogenetictechnologies for basic and clinical chromosome research
Analysis Medicine
Human genetics
Biomedicine
Cytogenetics
Cytology
Cell Biology
Notes Includes index
Bibliography Includes bibliographical references and index
Subject Human cytogenetics.
Human chromosomes.
Chromosomes, Human.
Cytogenetics.
Form Electronic book
Author I͡urov, I͡uriĭ Borisovich.
Vorsanova, S. G. (Svetlana Grigorʹevna)
I͡Urov, Ivan I͡Urʹevich.
LC no. 2013934476
ISBN 9781461465584 (electronic bk.)
1461465583 (electronic bk.)