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Title MTOR pathway and mTOR inhibitors in cancer therapy / Vitaly A. Polunovsky, Peter J. Houghton, editors
Published New York : Humana Press, [2010]
©2010
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Description 1 online resource (xii, 301 pages)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents mTORC1: a signalling integration node involved in cell growth -- The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions -- mTOR signaling in angiogenesis -- mTORC1 signaling and hypoxia -- mTOR signaling in glioblastoma: lessions learned from bench to bedside -- mTOR and cancer therapy: general principles -- mTOR and cancer therapy: clinical development and novel prospects -- Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer -- Downstream targets of mTORC1 -- Downstream of mTOR: translational and control of cancer -- Genome-wide analysis of translational control -- Translational control of cancer: implications for targeted therapy -- Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex
Summary MTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment - targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. In this work, experts in TOR signaling have contributed in two thematic areas: mTOR Signaling and Cancer Therapy (chapters 1 - 8) and Therapeutic Targeting Downstream of mTOR (chapter 9 - 13). All chapters of mTOR Pathway and mTOR Inhibitors in Cancer Therapy are completely new or have been extensively updated by their authors; and we are indebted to all authors who have exemplified the links between these 2 thematic areas
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cancer -- Treatment.
Antineoplastic Agents -- therapeutic use.
Enzyme Inhibitors -- therapeutic use.
Neoplasms -- drug therapy.
Protein-Serine-Threonine Kinases -- therapeutic use.
Form Electronic book
Author Polunovskiĭ, V. A. (Vitaliĭ Aleksandrovich)
Houghton, Peter J.
LC no. 2010930694
ISBN 9781603272711 (electronic bk.)
1603272712 (electronic bk.)
9781603272704
1603272704