| Description |
1 online resource (viii, 39 pages) : color illustrations |
| Series |
Colloquim series on the developing brain ; #2 |
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Colloquium series on the developing brain ; #2.
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| Contents |
1. Introduction |
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2. Formation of the telencephalic hemispheres |
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3. Midline tissue patterning: preparing the callosal substrate -- 3.1 Formation and development of the interhemispheric midline -- 3.1.1 Holoprosencephaly: how initial telencephalic midline formation affects callosal development -- 3.2 Interhemispheric midline fusion |
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4. Specification of callosal projection neurons within the neocortex and cingulate cortex -- 4.1 The neocortex -- 4.1.1 Satb2 specifies neocortical callosal projection neurons -- 4.2 The cingulate cortex -- 4.2.1 Emx2 regulates specification of cingulate pioneer projection neurons |
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5. Establishing the callosal tract -- 5.1 Axon extension and medial turning within the cortex -- 5.2 Axon-axon interactions: fasciculation |
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6. Navigating the midline: growth of the corpus callosum across the interhemispheric midline -- 6.1 Cellular architecture of the interhemispheric midline -- 6.1.1 Astrogliogenesis in the telencephalon -- 6.1.2 Malformations in the glial wedge and indusium griseum glia are associated with agenesis of the corpus callosum -- 6.1.3 The glial wedge -- 6.1.4 The indusium griseum glia -- 6.1.5 The subcallosal sling/midline corridor -- 6.2 Axonal guidance mechanisms at the interhemispheric midline -- 6.2.1 Semaphorin signalling -- 6.2.2 Slit signalling -- 6.2.3 Draxin signalling -- 6.2.4 Wnt signalling |
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7. Contralateral targeting of callosal axons: the role of neuronal activity |
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8. Conclusion -- References |
| Summary |
The corpus callosum is the largest fibre tract in the human brain and subserves many of the brain's higher-order functions. Disconnection syndromes resulting from surgical ablation, developmental absence (agenesis of the corpus callosum), disease, or injury of the corpus callosum can have profound consequences on cognition. Callosal development involves an intricate series of sequential and concurrent processes, including telencephalic induction, midline tissue patterning, production and specification of callosal neurons. In addition, axon extension and long-range axonal guidance from one hemisphere to the other are required for functional circuit formation in the contralateral hemisphere. Genetic or traumatic disruption to any part of this sequence is pathogenic. Understanding the key processes involved in callosal development is the first step in providing both better neuropsychological outcomes and improved diagnostic and prognostic tools for congenital disconnection syndromes in the future |
| Analysis |
brain wiring |
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forebrain |
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telencephalon |
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cerebral cortex |
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cortical development |
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astrogliogenesis |
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axon guidance |
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agenesis of the corpus callosum |
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holoprosencephly |
| Bibliography |
Includes bibliographical references (pages 31-39) |
| Subject |
Corpus callosum.
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Corpus Callosum -- growth & development
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Corpus Callosum
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MEDICAL -- Neuroscience.
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PSYCHOLOGY -- Neuropsychology.
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Corpus callosum
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| Form |
Electronic book
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| Author |
Richards, Linda J.
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| ISBN |
9781615040797 |
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161504079X |
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