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Author Ulloa-Aguirre, Alfredo.

Title Cellular Endocrinology in Health and Disease
Published Burlington : Elsevier Science, 2014
Online access available from:
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Description 1 online resource (416 pages)
Contents 880-01 Hypothyroidism Retards Tumor Growth but Increases Metastasis DevelopmentDivergent Effects of TRs on Normal and Transformed Cell Proliferation; Acknowledgements; References; 2 The Molecular Cell Biology of Anterior Pituitary Cells; Introduction; Anterior Pituitary: Organization, Cell Types, Hormones and Functions; Diseases of the Anterior Pituitary; Hypopituitarism; ACTH Deficiency; TSH Deficiency; LH, FSH Deficiencies; GH Deficiency; PRL Deficiency; Hyperpituitarism; Prolactinoma; Corticotropinoma; Somatotropinoma; Null Cell Adenomas; Gonadotrophic Adenomas; Thyrotrophic Adenomas
880-01 Front Cover; Cellular Endocrinology in Health and Disease; Copyright Page; Contents; List of Contributors; Preface; 1 Thyroid Hormone Receptors and their Role in Cell Proliferation and Cancer; Thyroid Hormone Action; TRs and Cancer; Inhibition of Tumor Cell Proliferation by the Thyroid Hormone Receptors; The Thyroid Hormone Receptor Antagonizes ras-Induced Proliferation; The Thyroid Hormone Receptors Antagonize Transformation and Tumorigenesis by Oncogenic Ras; Functional Domains Involved in TR Antagonism of Ras Responses; TRĪ²1 Suppresses Tumor Invasion and Metastasis
Location of Proliferating and Differentiating Cells During Pituitary DevelopmentStrategies for Identifying Pituitary Progenitors; Chromophobes Can Differentiate into All Anterior Pituitary Hormone-producing Cells; Pituitary Progenitors Absorb a Fluorescent Dipeptide and Have Folliculostellate Cell Characteristics; Pituitary Progenitors in the Side Population That Exhibit Rapid Hoechst Dye Efflux; Pituitary Progenitors in the SOX2-Positive Cell Population; Pituitary Progenitors Expressing GFRa2 and PROP1: Rodent and Human; Nestin-GFP Tagged Pituitary Progenitors
Phenotypic Profile of Anterior Pituitary Cell Types: Different, Yet Somewhat SimilarHeterogeneity within Anterior Pituitary Cell Types: Similar, Yet Somewhat Different; Patterns of Anterior Pituitary Cell Signaling and Secretion; Molecular Mechanisms Underlying Excitability and Basal Secretion; Receptor-Modulated Hormone Release and Voltage-Gated Ca2+ Influx through cAMP-Dependent Pathways; Receptor-Modulated Hormone Release through Ca2+-Mobilizing Pathways; Paracrine (Local) Regulation and Intercellular Signaling within the Anterior Pituitary
Plasticity of Anterior Pituitary Cell Network Organization and FunctionConcluding Remarks; Acknowledgements; References; 3 Sensing Calcium Levels: The Biology of the Parathyroid Cell; Introduction; Biosynthesis and Metabolism of PTH; Regulation of PTH Secretion and Transcription; Calcium-Sensing Properties of the Parathyroids: The CaSR; Phospate/FGF23 Regulation of the Parathyroids; Vitamin D Regulation of the Parathyroids; Main Mechanisms of Parathyroid Gland Hyperplasia in SHPT; Conclusions; References; 4 The Biology of Pituitary Stem Cells; Introduction
Summary Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue. Providing content that crosses disciplines, Cellular Endocrinology in Health
Notes Pituitary Progenitors and Disease Pathophysiology
Description based on print version record
Subject Endocrinology.
Form Electronic book
Author Conn, P. Michael.
ISBN 0124167128 (electronic bk.)
9780124167124 (electronic bk.)