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Book Cover
Streaming video
Author Kelly, Jeffery W. (The Scripps Research Institute, USA), speaker

Title Adapting proteostasis to ameliorate aggregation-associated amyloid diseases / Jeffery W. Kelly
Published London : Henry Stewart Talks, 2018
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (49 min.) : color, sound)
Series Protein epidemiology : understanding human diseases at the level of protein structure and function, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Protein folding, aggregation and design : concepts, experiments, theories and mechanisms
Contents Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Subject Amyloidosis -- Treatment.
Clinical trials.
Protein folding.
Proteins -- Metabolism -- Disorders.
Activating Transcription Factor 6 -- metabolism.
Amyloid -- metabolism.
Amyloidosis -- drug therapy.
Clinical Trials as Topic.
Protein Aggregates -- drug effects.
Unfolded Protein Response -- drug effects.
Genre/Form Video recordings.
Form Streaming video