A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility
Enzyme inhibitors -- Dictionaries : The inhibitor index : a desk reference on enzyme inhibitors, receptor antagonists, drugs, toxins, poisons, & therapeutic leads / Daniel L. Purich (Department of Biochemistry & Molecular Biology, University of Florida College of Medicine, Gainesville, Florida, U.S.A.)