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Author Metcalf, Donald.

Title The hemopoietic colony-stimulating factors : from biology to clinical applications / Donald Metcalf, Nicos Anthony Nicola
Published Cambridge : Cambridge University Press, 1995


Location Call no. Vol. Availability
Description xi, 329 pages : illustrations ; 24 cm
Contents 1. Historical introduction -- 2. General introduction to hemopoiesis -- 3. Key techniques in analyzing hemopoiesis -- 4. Biochemistry of the colony-stimulating factors -- 5. Biochemistry of the colony-stimulating factor receptors -- 6. Molecular genetics of the colony-stimulating factors and their receptors -- 7. Biological actions of the colony-stimulating factors in vitro -- 8. The biology of colony-stimulating factor production, degradation, and clearance -- 9. Actions of the colony-stimulating factors in vivo -- 10. Role of the colony-stimulating factors in basal hemopoiesis -- 11. Actions of the colony-stimulating factors in resistance to infections -- 12. Role of the colony-stimulating factors in other disease states -- 13. The colony-stimulating factors and myeloid leukemia -- 14. Clinical uses of the colony-stimulating factors -- 15. Conclusions
Summary This book provides a detailed and up-to-date account of the discovery of the CSFs, their structure, molecular biology, and cellular receptors, the biology of the CSFs in vivo and in vitro, and their present and possible future clinical applications. Written by two of the pioneers in the discovery of the CSFs, it is a clear and well-illustrated survey of the history, current knowledge, and future directions of this exciting field of investigation, and also serves as a guide to the more general areas of growth factor and cytokine research. It will prove an invaluable review for cell biologists interested in how growth factors act on the body, as well as for clinicians applying the fruits of modern biotechnology to improved patient care
Bibliography Includes bibliographical references (pages 269-327) and index
Subject Colony-stimulating factors (Physiology)
Receptors, Colony-Stimulating Factor
Colony-Stimulating Factors.
Receptors, Colony-Stimulating Factor.
Genre/Form Catalogs.
Author Nicola, Nicos, 1950-
LC no. 94023237
ISBN 0521461588 (hc)