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Title Acinetobacter biology and pathogenesis / Eugénie Bergogne-Bérézin, Herman Friedman, Mauro Bendinelli, editors
Published New York : Springer, [2008]
©2008
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Description 1 online resource (xvi, 220 pages) : illustrations
Series Infectious agents and pathogenesis
Infectious agents and pathogenesis.
Contents History and Importance of Acinetobacter spp -- Overview of the Microbial Characteristics, Taxonomy and Epidemiology of Acinetobacter -- Genome Organization, Mutation and Gene Expression in Acinetobacter -- Molecular Epidemiology of Acinetobacter Species -- Typing Acinetobacter Strains: Application and Methods -- Efflux Pumps in Acinetobacter baumannii -- Acinetobacter baumannii: Mechanisms of Resistance, Multiple ß-Lactamases -- Virulence Mechanisms of Acinetobacter -- Clinical Experience, Nosocomial Infections, Community Acquired Acinetobacter Infections -- Experimental Models of Acinetobacter Infection -- Antimicrobial Resistance and Therapeutic Alternatives -- US Army Experience with Acinetobacter in Operation Iraqi Freedom -- Perspectives
Summary There is currently increasing interest concerning the biology and disease caused by Acinetobacter species. Such interest, however, developed relatively slowly because of the necessity to clarify the confusing taxonomy of these organisms. Much work was needed to identify various species as members of this genus, to recognize their epidemiologic profile, their pathogenic role and their increasing importance as multi-antibiotic resistant organisms. In recent years improvement of genetic approaches, recognition of plasmids, integrons and chromosomal sources of resistance mechanisms aroused interest on the role of Acinetobacters in disease by many microbiologists and clinicians, especially internists and infectious disease specialists. In this regard, physicians are frequently confronted with extremely difficult therapeutic approaches for treatment and prevention of severe nosocomial infections due to multi antibiotic resistant Acinetobacter. Moreover, recent observations of community acquired infections have been reported, especially in patients with various risk factors such as immuno-deficiencies. Also, it is now becoming evident that Acinetobacter infections occur frequently in violent situations such as earthquake or war zones. The mechanisms of Acinetobacter virulence are becoming increasingly clear, providing new insights into their pathogenic role in community acquired infections. It is apparent the time is appropriate for detailed review of the increasing knowledge concerning important new information, both clinical and therapeutic, especially information concerning virulence, resistance mechanisms and typing of Acinetobacter spp. Many new findings are accumulating in almost an exponential manner since publication of previous books on this subject in 1991 and 1996
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Acinetobacter infections.
Acinetobacter.
Nosocomial infections.
Acinetobacter -- pathogenicity.
Acinetobacter Infections -- microbiology.
Anti-Bacterial Agents -- therapeutic use.
Cross Infection -- microbiology.
Form Electronic book
Author Bendinelli, Mauro.
Bergogne-Bérézin, E.
Friedman, Herman, 1931-2007.
LC no. 2008932526
ISBN 0387779434
0387779442
6611954198
9780387779430
9780387779447
9786611954192