| Description |
1 online resource |
| Contents |
<B>Part I -- Fundamentals of Inflammasome Biology</b> <br>1. Overview of inflammatory processes at cellular level<br>2. Inflammasome formation and triggers<br>3. Cellular signaling, molecular activation and regulation of the NLRP1 inflammasome<br>4. Cellular signaling, molecular activation and regulation of the NLRP3 inflammasome<br>5. Cellular signaling, molecular activation and regulation of the NLRP6 inflammasome<br>6. Cellular signaling, molecular activation and regulation of the NLRC4 inflammasome<br>7. Cellular signaling, molecular activation and regulation of the AIM2 inflammasome<br>8. Cellular signaling, molecular activation and regulation of the Pyrin inflammasome<br>9. Cellular signaling, molecular activation and regulation of the non-canonical inflammasome<br>10. Cellular signaling, molecular activation and regulation of auto-active inflammasomes<br>11. Autophagy and the inflammasome<br>12. Inflammasome effector functions<br>13. Inflammatory caspases<br>14. Structural aspects of inflammasomes<br>15. Evolutive aspects of inflammasomes<br><br><b>Part II -- inflammasome role in disease processes <br></b>16. The inflammasome in cardiovascular diseases <br>17. Inflammasome implications in metabolic disorders <br>18. Inflammasome in venous thromboembolic disorders <br>19. Inflammasomes and neurodegenerative diseases<br>20. Inflammasome implication in diseases of the respiratory system<br>21. Inflammasomes and their regulation in oral disease <br>22. Inflammasomes in inflammatory bowel disease pathogenesis <br>23. Inflammasome induced inflammation and fibrosis in liver<br>24. Inflammasomes in sepsis<br>25. The Inflammasome in viral, bacterial and fungal infections<br>26. Autoinflammatory syndromes<br>27. The inflammasome in graft-versus-host disease<br>28. Implication of the inflammasomes in rheumatic diseases<br>29. The inflammasomes in kidney disease<br>30. Inflammasomes and cancer<br>31. Inflammasomes in the pathobiology of degenerative retinopathies.<br><br><b>Part III -- Inflammasome crosstalk in Cell Death <br></b>32. Regulation of pyroptosis by inflammasomes.<br>33. Crosstalk between necroptosis and inflammasome.<br>34. Apoptosis and inflammasome regulation<br>35. Implication of inflammasomes regulating different types of cell death<br>36. Regulation of neutrophil NETosis by inflammasomes<br><br><b>Part IV -- Therapeutic Opportunities</b> <br>37. Therapeutic opportunities targeting the inflammasome<br>38. Development of selective inflammasome Inhibitors<br>39. Natural compounds blocking inflammasomes<br>40. Inhibitors targeting inflammasome effectors<br>41. Multi-inflammasome inhibitors |
| Summary |
Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds |
| Notes |
Print version record |
| Subject |
Inflammation -- Mediators.
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Inflammation -- Immunological aspects.
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Inflammation Mediators
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Inflammation -- Immunological aspects
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Inflammation -- Mediators
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| Form |
Electronic book
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| Author |
Pelegrin, Pablo
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| ISBN |
9780323972062 |
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0323972063 |
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