| Description |
1 online resource (539 pages) |
| Series |
Subcellular Biochemistry ; v. 97 |
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Sub-cellular biochemistry ; v. 97.
|
| Contents |
Intro -- Preface -- EVs: A Diverse Community -- Functional Role and Clinical Implications of EVs -- Contents -- About the Editors -- Part I: Subtypes, Biogenesis, and Secretion of Extracellular Vesicles -- Chapter 1: Introduction to the Community of Extracellular Vesicles -- Introduction -- Subtypes of EVs -- Molecular Composition of EVs -- Isolation and Characterisation of EVs -- Concluding Remarks -- References -- Chapter 2: Biogenesis of Extracellular Vesicles -- Introduction: Extracellular Vesicles -- Large Oncosomes -- Apoptotic Bodies -- Migrasomes -- Ectosomes/Shedding Microvesicles |
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Exosomes -- ESCRT-Dependent Pathway of ILV Biogenesis -- ESCRT-Independent Pathway of ILV Biogenesis -- Role of Tetraspanins in Biogenesis of Exosomes -- Secretion of Exosomes -- Exomeres -- Concluding Remarks -- References -- Chapter 3: The Role of Post-Translational Modifications in Targeting Protein Cargo to Extracellular Vesicles -- Introduction -- Phosphorylation -- Glycosylation -- Ubiquitination -- SUMOylation -- Oxidation -- Citrullination -- ISGylation -- Myristoylation -- Palmitoylation -- Concluding Remarks -- References |
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Chapter 4: Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance -- Introduction -- Mechanisms of Apoptotic Cell Disassembly -- Step 1: Plasma Membrane Blebbing -- Step 2: Apoptotic Membrane Protrusion Formation -- Pannexin 1 -- Plexin B2 -- Cytoskeleton -- Vesicle Trafficking -- Step 3: ApoBD Fragmentation -- Maintenance of Plasma Membrane Integrity to Prevent Premature Lysis -- Methods of ApoBD Isolation -- Differential Centrifugation -- Filtration -- Fluorescence-Activated Cell Sorting (FACS) -- Validation of ApoBDs -- Functional Significance of ApoBD Formation |
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ApoBDs in Cell Clearance -- ApoBDs in Intercellular Communication -- Intercellular Communication Through DNA as Cargos -- Intercellular Communication Through RNA as Cargos -- Intercellular Communication Through Proteins as Cargos -- Intercellular Communication Through Pathogen-Derived Material -- Concluding Remarks -- References -- Chapter 5: Exomeres: A New Member of Extracellular Vesicles Family -- Introduction -- Exomeres -- Proteomic Cargo of Exomeres -- Isolation of Exomeres -- Concluding Remarks -- References -- Part II: Functional Role and Clinical Implications of Extracellular Vesicles |
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Chapter 6: Pathogenesis Mediated by Bacterial Membrane Vesicles -- Introduction -- What are Bacterial Membrane Vesicles? -- The Study of BMVs -- Isolation and Purification -- Characterisation & Analysis -- BMV Biogenesis -- Mechanisms of OMV Biogenesis -- Mechanisms of MV Biogenesis -- Cargo Packaging into BMVs -- Physiological Roles of BMVs -- Physiological Roles of OMVs Produced by Gram-Negative Bacteria -- Biofilm Formation -- Nutrient Acquisition -- Competition and Predation -- Bacterial Defence -- Horizontal Gene Transfer -- Physiological Roles of MVs Produced by Gram-Positive Bacteria |
| Summary |
The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base |
| Notes |
Pathogen-Derived BMVs Can Modulate the Host Immune Response |
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Includes index |
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Print version record |
| Subject |
Extracellular space.
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Cell organelles.
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Extracellular Space
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Cell organelles
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Extracellular space
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Espai extracel·lular.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Mathivanan, Suresh.
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Fonseka, Pamali
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Nedeva, Christina
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Atukorala, Ishara
|
| ISBN |
9783030671716 |
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3030671712 |
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9783030671723 |
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3030671720 |
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9783030671730 |
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3030671739 |
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