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Title New therapeutics for traumatic brain injury : prevention of secondary brain damage and enhancement of repair and regeneration / edited by Kim A. Heidenreich
Published London : Academic Press is an imprint of Elsevier, [2017]
Online access available from:
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Description 1 online resource (xxv, 325 pages) : illustrations (some color)
Contents Part I: Interventional therapies for TBI previously or currently in phase 3 clinical trials. Why did the phase III clinical trials for progesterone in TBI fail? An analysis of three potentially critical factors / D.G. Stein, R.B. Howard, I. Sayeed -- Hypothermia for traumatic brain injury: current evidence and future directions / H. Mtaweh, D. Simon, M.J. Bell -- The future of TBI: hyperbaric oxygen as a primary therapeutic approach / B. Miskin, L.A. Fox -- Part II: Repurposing FDA approved drugs for TBI treatment. Erythropoietin and its derivatives: mechanisms of neuroprotection and challenges in clinical translation / T. Bogoslovsky, J.D. Bernstock, K. Kenney, C. Moore, R. Diaz-Arrastia -- Atorvastatin in the treatment of traumatic brain injury / A.N. Sen, S.P. Gopinath, C.S. Robertson -- The application of glibenclamide in traumatic brain injury / D.S. Hersh, J.M. Simard, H.M. Eisenberg -- Perispinal etanercept for traumatic brain injury / E. Tobinick, H. Rodriguez-Romanacce, R. Kinssies, N. Kim -- Part III: Interventional drugs for TBI in phase 1-2 clinical trials. Nitric oxide synthase inhibitors in traumatic brain injury / R. Schinzel, F. Tegtmeier -- Management of paroxysmal sympathetic hyperactivity after traumatic brain injury / L.D. Wilson, T.C. Leath, M.B. Patel -- Part IV: Interventional drugs for TBI in preclinical development. The use of estrogen for the treatment of traumatic brain injury / W.J. Hubbard, I.H. Chaudry -- Voltage-gated calcium channel blockers for the treatment of traumatic brain injury / G.G. Gurkoff, K. Shahlaie, B.G. Lyeth, R.F. Berman -- 5-lipoxygenase-activating protein inhibitors: promising drugs for treating acute and chronic neuroinflammation following brain injury / K.A. Heidenreich, C.E. Corser-Jensen -- Carbonyl scavenging as an antioxidant neuroprotective strategy for acute traumatic brain injury / J.E. Cebak, I.N. Singh, J.A. Wang, R.L. Hill, J.R. Kulbe, E.D. Hall -- TrkB receptor agonist 7,8-Dihydroxyflavone and its therapeutic potential for traumatic brain injury / J. Romeika, M. Wurzelmann, D. Sun -- Ceftriaxone treatment of TBI / M.Q. Hameed, A. Rotenberg -- Part V: Drugs for TBI rehabilitation. Memantine: a safe and tolerable NMDA antagonist with potential benefits in traumatic brain injury / M.A. Keiski -- Interventional drugs for TBI Rehabilitation of cognitive impairment: the cholinesterase inhibitor rivastigmine / M.A. Hernandez-Tejada, O. Brawman-Mintzer -- Docosahexaenoic acid and omega 3 fatty acids / M.E. Schober -- Treatment of mood disorders following traumatic brain injury / H.L. Lin, R.E. Jorge
Summary "New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury"--Publisher's description
Bibliography Includes bibliographical references and index
Notes Online resource; title from electronic title page (ScienceDirect viewed March 27, 2018)
Subject Brain damage -- Rehabilitation.
Brain damage -- Treatment.
Brain -- Wounds and injuries -- Complications.
Brain Injuries, Traumatic -- complications.
Brain Injuries, Traumatic -- drug therapy.
Brain -- drug effects.
Clinical Trials as Topic.
Form Electronic book
Author Heidenreich, Kim A., editor
ISBN 0128027010 (electronic bk.)
9780128027011 (electronic bk.)