| Description |
1 online resource |
| Contents |
Governing Principles of Brain Activity / Edgar Gracia-Rill -- Why Waking? -- The Gorilla in the Room -- Cell Assemblies -- Coherence and Frequency -- Content and Context -- Cortical Columns -- Thalamocortical Resonance -- Clinical Implications: Thalamocortical Dysrhythmia -- References -- The EEG and the Discovery of the RAS Edgar Gakcia-Rill / Christ En Simon -- The EEG and the RAS -- Limitations of the EEG -- Early Theories of Sleep -- The Pedunculopontine Nucleus -- Dorsal and Ventral Cholinergic Pathways -- Clinical Implications: "Sleep Problems" vs. "Waking Problems" -- References -- Other Regions Modulating Waking / Edgar Garcia-Rill -- A Matter of Time -- The Lateral Hypothalamus and Hypocretin -- The Basal Forebrain and Acetylcholine -- The TMN and Histamine -- Clinical Implications: Coma -- References -- Wiring Diagram of the RAS / Susan Mahaffey, Edgar Garcia-Rill -- Wiring Diagram -- Locus Coeruleus -- Dorsal Raphe Nucleus -- Pedunculopontine Nucleus -- Intrinsic Properties of PPN Neurons -- Inputs to PPN Neurons -- Electrical Coupling -- Cell Clusters -- Clinical Implications -- References -- Development and the RAS / Paige Beck, Edgar Garcia-Rill -- Development of Wake-Sleep States -- Evolutionary Considerations -- Developmental Decrease in REM Sleep -- REM Sleep Inhibition -- Changes in Intrinsic Properties -- Changes in Transmitter Responses -- Puberty and Wake-Sleep -- Gonadal Steroids -- Clinical Implications -- References -- Ascending Projections of the RAS / James Hyde, Edgar Garcia-Rill -- The Ascending Reticular Activating System -- Intralammar Thalamus -- Cortex -- Clinical Implications -- References -- Descending Projections of the RAS / Charlotte Yates, Edgar Garcia-Rill -- Descending Targets -- The Subcoeruleus Nucleus -- The PPN and the MLR -- Posture and Locomotion -- Push-Pull on Reticulospinal Cells -- The Startle Response -- Spinal Cord -- Clinical Implications -- References -- The 10 Hz Fulcrum / Edgar Garcia-Rill -- Alpha Frequency ( -10 Hs) Activity -- Alpha Rhythm -- The mu Rhythm -- Physiological Tremor -- The 10 Hz: Fulcrum -- Natural Frequency -- Clinical Implications -- References -- Gamma Band Activity / Nebojsa Kezunovic, James Hyde, Francisco J. Urbano, Edgar Garcia-Rill -- What does the EEG measure? -- Binding and Perception -- Cortical Mechanisms of Gamma Band Activity -- Coordination of Gamma Band Activity -- RAS Mechanisms of Gamma Band Activity -- Gamma Maintenance -- Gamma in Waking vs. REM Sleep -- Clinical Implications -- References -- Preconscious Awareness / Edgar Garcia-Rill -- The Role of Gamma Band Activity in the RAS -- Levels of Awareness -- Waking and Preconscious Awareness -- Volition and Free Will -- Mechanisms for Preconscious Awareness -- Everyday Preconscious Awareness -- The PPN and Behavior -- Clinical Implications -- References -- Psychiatric Disorders and the RAS / Stasia D'Onofrio, Erick Messias, Edgar Garcia-Rill -- Arousal Waking, and Psychiatric Disorders -- Schizophrenia -- Bipolar Disorder -- Major Depression -- Posttraumatic Stress Disorder -- Attention Deficit Hyperactivity Disorder -- Autism -- Clinical Implications -- References -- Neurological Disorders and the RAS / Brennon Luster, Erica Petersen, Edgar Garcia-Rill -- Arousal, Waking, and Neurological Disorders -- Parkinson's Disease -- Alzheimer's Disease -- Huntington's Disease -- Insomnia -- Neglect -- Clinical Implications -- References -- Drug Abuse and the RAS / Francisco J. Urbano, Veronica Bisagno, Edgar Garcia-Rill -- Waking and Drug Abuse -- Stimulants -- Depressants -- Clinical Implications -- Acknowledgments -- References -- The Science of Waking and Public Policy / Edgar Garcia-Rill -- Three States -- Wakefulness and Performance -- Intent -- Genetics -- Functional Magnetic Resonance Imaging -- The Future of Science -- Waking and Public Policy -- Changing Directions -- Brain Music -- References |
| Summary |
Annotation Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the "activating" properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson's disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders. First comprehensive overview on the RAS and its role in schizophrenia, major depression, autism, Parkinson's, Alzheimer's, and other neurologic and mental diseasesOffers a new way of thinking about brain function and the role of the RAS in our waking livesWritten by a leading translational neuroscience researcher with contributions by specialists in the field |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed May 7, 2015) |
| Subject |
Wakefulness.
|
|
Reticular formation.
|
|
Wakefulness
|
|
Reticular Formation
|
|
TECHNOLOGY & ENGINEERING -- Mechanical.
|
|
Reticular formation
|
|
Wakefulness
|
| Form |
Electronic book
|
| Author |
Garcia-Rill, Edgar, editor.
|
| ISBN |
9780128016329 |
|
0128016329 |
|
0128013850 |
|
9780128013854 |
|
