| Description |
1 online resource (441 p.) |
| Contents |
Intro -- Preface -- Acknowledgments -- Contents -- About the Authors -- 1: Protein Networks in Human Disease -- 1.1 Introduction to Genetic Basis of Disease -- 1.2 Classical Protein Complexes in the Cell -- 1.3 Characterization of Disease-Related Mutations at Protein Interaction Interfaces -- 1.4 Role of Protein Interactions in Disease -- 1.5 Impact of Protein Interaction Networks on Analysis of Disease Genes: A Case Study -- 1.5.1 Potential Therapeutic Drug Targets in COVID-19 -- 1.5.2 Drug Repurposing Strategy -- 1.6 Intrinsic Disorder-Based Human Diseases |
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1.7 PPIs in GPCR-Related Diseases -- 1.8 PPIs Related to Cataract Formation -- 1.8.1 Etiology of Cataract -- 1.9 PPIs Involved in Cystic Fibrosis -- 1.10 PPIs in Ubiquitin-Proteasome Pathway -- 1.11 PPIs in MODY (Maturity Onset Diabetes of the Young) Family -- 1.12 Conclusion -- References -- 2: Protein-Protein Interactions in Cancer -- 2.1 Introduction to Cancer -- 2.2 Profiling PPIs of Single Cancer Cells -- 2.3 Building Cancer Cell Maps -- 2.4 OncoPPI Portal -- 2.5 PPIs Between Growth Factors/Chemokines and Their Receptors -- 2.6 PPIs for Cytoskeleton Dynamic Pathways |
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3.4.4 Parkin (PARK2) -- 3.4.5 Apolipoprotein E (APOE) -- 3.5 Amyotrophic Lateral Sclerosis (ALS) -- 3.5.1 TAR DNA-Binding Protein-43 (TDP-43) -- 3.5.2 Superoxide Dismutase-1 (SOD1) -- 3.5.3 Fused in Sarcoma (FUS) -- 3.6 Huntington Disease -- 3.6.1 Transcription Factors -- 3.6.2 Autophagy-Related Protein -- 3.6.3 Cell Division-Related Proteins -- 3.6.4 Trafficking Vesicle-Associated Proteins -- 3.7 Spinal Muscular Atrophy -- 3.7.1 Plastin 3 (PLS3) -- 3.7.2 Gemins -- 3.7.3 Profilins (PFN) -- 3.8 Frontotemporal Dementia (FTD) -- 3.8.1 Tau Protein -- 3.8.2 Progranulin |
| Summary |
The second volume of the book-Protein-Protein Interactions (PPIs) provides an overview of various protein-protein interactions (PPIs) that are involved in various human diseases including cancer, neurodegenerative diseases, immune diseases, and inflammation. It summarizes the structure and ligand-based drug designing approaches for the discovery of small molecules that can inhibit PPIs in these diseases. The book discusses different computational and experimental tools that are used to determine the anomalous interactions underlying the diseases. Lastly, it also reviews the classical interactions between pathogens and hosts that are responsible for the pathophysiology of infectious diseases |
| Notes |
3.8.3 Valosin-Containing Protein (VCP) |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed August 28, 2023) |
| Subject |
Protein-protein interactions.
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| Form |
Electronic book
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| Author |
Gulati, Khushboo.
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Tripathi, Deepak Kumar
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Nagar, Nupur
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| ISBN |
9789819924233 |
|
9819924235 |
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