| Description |
1 online resource |
| Contents |
Intro; Preface; Contents; Part I: Epidemiology and Diagnosis; The Role of Vaccination in the Prevention of Head and Neck Cancer; Introduction; HPV Vaccines; Early End-Points; Herd Effects; The Effect of Vaccinating Boys on Cancer in Men; Vaccination Coverage and Programme Resilience; Economic Considerations; Conclusions; References; Cellular and Molecular Pathology in Head and Neck Cancer; Introduction; International Datasets and the WHO Classification; Molecular Sequencing; Stromal Factors; Immunological Landscape; Digital Pathology and Image Analysis; Biomarkers in Current Practice |
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Molecular Pathology and Salivary DiagnosticsReferences; Part II: Prediction of Outcome; Oncogenomics/Proteomics of Head and Neck Cancer; Oncoproteomics; Head and Neck Cancer Classification; Anatomical Classification of Head and Neck Cancers; Genetic Subclassification; HPV−ve Tumors; HPV+ve Tumors; Tumor Classifications by Oncogenomics; References; Targeted Next-Generation Sequencing in Head and Neck Cancer; Optimization of Cancer Treatment Based on Cancer Genomics; Targeted Therapy of Head and Neck Cancer; Comprehensive NGS Studies Reveal a Complex Genetic Landscape in HNSCC |
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Precision Oncology by Targeted Panel SequencingExploiting NGS Results for the Clinical Development of Targeted Therapies; Intratumoral Genomic Heterogeneity in HNSCC: A Challenge for Personalized Medicine?; Conclusions; References; Homologous Recombination Repair Function as a Predictor of Treatment Response; Introduction; Molecular Responses to Radiation-/Chemoradiation-Induced DNA Damage; Measuring HRR Function to Predict Response to Radiotherapy/Chemoradiotherapy; Targeting HRR Function to Sensitise Tumors to Radiotherapy/Chemoradiotherapy |
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Targeting G2/M Checkpoint Control Through ATR or Chk1 InhibitionATR Inhibitors; Chk1 Inhibitors; Conclusions; References; Part III: Oral Cavity Cancer; Surgical Management of Oral Cavity Cancer; Introduction; Tumor Factors; Patient Factors; Other Factors; Surgical Access to Oral Cancer; Outcome; References; Reconstruction in the Oral Cavity: When and How; Introduction; Reconstruction of Soft Tissue Defects; Tongue and Floor of Mouth Defects; Aims of Treatment; Options for Treatment; Buccal Mucosa Defects; Aims of Treatment; Options for Treatment; Post-operative Care; Soft Palate Defects |
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Aims of TreatmentOptions for Treatment; Reconstruction of Bony Defects; Mandibular Defects; Choice of Flaps for Mandibular Reconstruction; Maxillary Defects; Options for Reconstruction; Choice of Flaps for Maxillary Reconstruction; Dental Rehabilitation; Conclusions; References; Induction Chemotherapy: Does It Have a Place in Oral Cavity Cancer?; Data from Meta-Analyses; Induction Chemotherapy for "Unresectable" or "Unresected" Oral Cavity Cancer; Induction Chemotherapy Before Surgery for Oral Cavity Cancer: Randomized Trials; Conclusions; References |
| Summary |
This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Commencing with a discussion of epidemiological and diagnostic aspects, including the role of vaccination and key pathological features, the book then follows by examining the role of oncogenomics, proteomics, next generation sequencing and homologous recombination function in predicting outcomes. The topics are presented by epidemiologists, pathologists and basic scientists with further contributions from medical oncologists, head and neck cancer surgical specialists (ORL /HNS), and radiation oncologists in chapters that discuss therapeutic approaches for oral, oropharyngeal and thyroid cancer. Special topics such as the development of novel staging classifications, optimal larynx preservation approaches for laryngeal and hypopharyngeal cancer, surgical reconstruction, new surgical approaches in oropharynx cancer, potential for treatment de-escalation, systemic therapy in nasopharyngeal cancer and salivary gland tumors and treatment approaches for tumors of unknown primary site are discussed in detail. Finally, the role of immunotherapy in the field is highlighted. The chapters are based on the latest data presented at the 6th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. They are written by many of the most internationally acclaimed authors in the field and are therefore an excellent source for all those interested or actively working in the field of head and neck cancer |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Alternative Local Treatment in Oral Cavity Cancer: Photodynamic Therapy |
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Online resource; title from digital title page (viewed on December 13, 2018) |
| In |
Springer eBooks |
| Subject |
Head -- Cancer -- Congresses
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Neck -- Cancer -- Congresses
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Head and Neck Neoplasms -- diagnosis
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Clinical Decision-Making
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Head and Neck Neoplasms -- therapy
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Radiotherapy.
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Oncology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Head -- Cancer
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Neck -- Cancer
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| Genre/Form |
proceedings (reports)
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Conference papers and proceedings
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Conference papers and proceedings.
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Actes de congrès.
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| Form |
Electronic book
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| Author |
Vermorken, Jan B., editor.
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| ISBN |
9783319988542 |
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3319988549 |
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