| Description |
1 online resource (xxviii, 900 pages) : color illustrations |
| Series |
Biological and medical physics, biomedical engineering, 2197-5647 |
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Biological and medical physics, biomedical engineering. 2197-5647
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| Contents |
Intro -- Preface -- Contents -- Introduction into Biophysics and Basic Biological Processes from a Physical Point-of-view -- 1 The Definition of Biophysics: What Exactly is Biophysics? -- Abstract -- 1.1 Introduction to Biophysics -- 1.2 Historical Overview of Selected Early Developments in Biophysics with a Focus on Cell Mechanics -- 1.2.1 Isolated Protoplasmic Mechanics -- 1.2.2 Future View on Cell Mechanics -- 1.3 Major Fields of Biophysics -- 1.4 Molecular Biophysics -- 1.4.1 Subdiscipline: Structural Molecular Biophysics -- 1.4.2 Subdiscipline: Nanotechnology -- 1.5 Systems Biophysics |
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1.5.1 Subdiscipline: Immunological Systems Biophysics -- 1.5.2 Subdiscipline: Developmental and Evolutionary Systems Biophysics -- 1.6 Biophysics-Related Discipline: Biophysical Chemistry -- 1.7 Cellular Biophysics -- 1.7.1 Subdiscipline: Membrane Cellular Biophysics -- 1.7.2 Subdiscipline: Nuclear Cellular Biophysics -- 1.8 Cellular Mechanics -- 1.9 Biophysical Bioengineering of the Cellular Microenvironment -- 1.10 "Experimental" Biophysics is Guided by Theoretical Biophysics -- 1.11 Short Introduction into Biophysical Models Quantifying Cell Mechanics |
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1.12 Why Are These Quantitative Models Usually Idealized? -- 1.12.1 What is the Conceptual Framework? -- 1.12.2 Unifying Ideas of Biological Processes -- 1.12.3 What Are the Unifying Ideas of Biology? -- 1.12.4 Why Do We Need Mathematics? -- 1.12.5 What Role Play Numbers in Cell Mechanics and Biophysics? -- References -- 2 Focus on Eukaryotic Cells -- Abstract -- 2.1 What Is Biological Soft Matter in General? -- 2.2 Four Major Classes of Macromolecules -- 2.3 Why Are Physical Models Needed and Kept Simple? -- 2.4 Characteristics of Prokaryotes and Eukaryotes -- 2.4.1 Prokaryotic Cells |
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2.4.2 Eukaryotic Cells -- 2.5 Organelles-What Defines Them? -- 2.6 Endosymbiotic Hypothesis -- 2.7 Single or Serial Endosymbiosis -- 2.8 How Can Eukaryotes Lose Their Mitochondria? -- References -- 3 Biomechanical View on the Cytoplasm (and Cytosol) of Cells -- Abstract -- 3.1 Biomechanical Picture of the Cytoplasm -- 3.1.1 Cells Serve as an Example for Engineered Designs -- 3.1.2 Cells Are Treated as Gels -- 3.1.3 Dynamics of Cells -- 3.1.4 Cells, Gels and Motion -- 3.2 Anisotropic Mechanics and Dynamics of the Cytoplasm of Living Cells |
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3.3 Relation Between the Shape of the Nucleus and Cytoskeletal Mechanics -- 3.4 Cytoplasm Mechanics Are Size- and Velocity-Dependent -- References -- 4 Focal Adhesion Proteins Regulate Cell-Matrix and Cell-Cell Adhesion and Act as Force Sensors -- Abstract -- 4.1 Introduction to Cell-Matrix Adhesion -- 4.1.1 The Major Adhesion Types -- 4.1.2 Focal Point Contacts -- 4.1.3 Focal Adhesions -- 4.1.4 Fibrillar Adhesions -- 4.2 Focal Adhesions and Focal Adhesion Proteins -- 4.2.1 Vinculin and Interacting Proteins -- 4.2.2 Activation of Vinculin -- 4.2.3 Role of Vinculin in Cell-Matrix Adhesions |
| Summary |
Focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, microbiological, viral, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Cells -- Mechanical properties.
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Biophysics.
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Biophysics
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Cells -- Mechanical properties
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Biomedical engineering
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Biophysics
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Cell physiology
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Immunology
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| Form |
Electronic book
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| ISBN |
9783030585327 |
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3030585328 |
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