| Description |
1 online resource (3194 pages) : illustrations (chiefly color) |
| Contents |
Cover Page; Title Page; Copyright Page; Dedication; Brief Contents; Contents; Preface; About the Authors; PART I Genes and Chromosomes; Chapter 1 Genes Are DNA and Encode RNAs and Polypeptides; 1.1 Introduction; 1.2 DNA Is the Genetic Material of Bacteria and Viruses; 1.3 DNA Is the Genetic Material of Eukaryotic Cells; 1.4 Polynucleotide Chains Have Nitrogenous Bases Linked to a Sugar-Phosphate Backbone; 1.5 Supercoiling Affects the Structure of DNA; 1.6 DNA Is a Double Helix; 1.7 DNA Replication Is Semiconservative; 1.8 Polymerases Act on Separated DNA Strands at the Replication Fork |
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1.9 Genetic Information Can Be Provided by DNA or RNA1.10 Nucleic Acids Hybridize by Base Pairing; 1.11 Mutations Change the Sequence of DNA; 1.12 Mutations Can Affect Single Base Pairs or Longer Sequences; 1.13 The Effects of Mutations Can Be Reversed; 1.14 Mutations Are Concentrated at Hotspots; 1.15 Many Hotspots Result from Modified Bases; 1.16 Some Hereditary Agents Are Extremely Small; 1.17 Most Genes Encode Polypeptides; 1.18 Mutations in the Same Gene Cannot Complement; 1.19 Mutations May Cause Loss of Function or Gain of Function; 1.20 A Locus Can Have Many Different Mutant Alleles |
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1.21 A Locus Can Have More Than One Wild-Type Allele1.22 Recombination Occurs by Physical Exchange of DNA; 1.23 The Genetic Code Is Triplet; 1.24 Every Coding Sequence Has Three Possible Reading Frames; 1.25 Bacterial Genes Are Colinear with Their Products; 1.26 Several Processes Are Required to Express the Product of a Gene; 1.27 Proteins Are trans-Acting but Sites on DNA Are cis-Acting; Chapter 2 Methods in Molecular Biology and Genetic Engineering; 2.1 Introduction; 2.2 Nucleases; 2.3 Cloning; 2.4 Cloning Vectors Can Be Specialized for Different Purposes; 2.5 Nucleic Acid Detection |
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2.6 DNA Separation Techniques2.7 DNA Sequencing; 2.8 PCR and RT-PCR; 2.9 Blotting Methods; 2.10 DNA Microarrays; 2.11 Chromatin Immunoprecipitation; 2.12 Gene Knockouts, Transgenics, and Genome Editing; Chapter 3 The Interrupted Gene; 3.1 Introduction; 3.2 An Interrupted Gene Has Exons and Introns; 3.3 Exon and Intron Base Compositions Differ; 3.4 Organization of Interrupted Genes Can Be Conserved; 3.5 Exon Sequences Under Negative Selection Are Conserved but Introns Vary; 3.6 Exon Sequences Under Positive Selection Vary but Introns Are Conserved |
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3.7 Genes Show a Wide Distribution of Sizes Due Primarily to Intron Size and Number Variation3.8 Some DNA Sequences Encode More Than One Polypeptide; 3.9 Some Exons Correspond to Protein Functional Domains; 3.10 Members of a Gene Family Have a Common Organization; 3.11 There Are Many Forms of Information in DNA; Chapter 4 The Content of the Genome; 4.1 Introduction; 4.2 Genome Mapping Reveals That Individual Genomes Show Extensive Variation; 4.3 SNPs Can Be Associated with Genetic Disorders; 4.4 Eukaryotic Genomes Contain Nonrepetitive and Repetitive DNA Sequences |
| Summary |
Long considered the quintessential molecular biology textbook, for decades Lewin's Genes has provided the most modern presentation to this transformative and dynamic science. Now in its twelfth edition, this classic text continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their respective areas of study offering readers current research and relevant information on the rapidly changing subjects in molecular biology. No other text offers a broader understanding of this exciting and vital science or does so with higher quality art and illustrations. Lewin's Genes XII continues to be the clear choice for molecular biology and genetics |
| Notes |
4.5 Eukaryotic Protein-Coding Genes Can Be Identified by the Conservation of Exons and of Genome Organization |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Genetics.
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Genes.
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Genes
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Genetics
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genetics.
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SCIENCE -- Life Sciences -- Evolution.
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Genes
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Genetics
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| Form |
Electronic book
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| Author |
Goldstein, Elliott S., author.
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Kilpatrick, Stephen T., author.
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| ISBN |
1284104516 |
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9781284104516 |
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