| Description |
1 online resource (335 p.) |
| Contents |
Intro -- Half Title -- Title Page -- Copyright Page -- Contents -- Contributors -- Abbreviations -- Preface -- Foreword -- Section I: Basic Mechanisms -- 1. Cellular and Immunobiology -- Cell Structure -- Cell (Plasma) Membrane -- Cytoplasmic Organelles -- Nucleus -- Endoplasmic Reticulum (ER) -- Golgi Apparatus -- Mitochondria -- Intracellular Molecules -- Proteins -- Lipids -- Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) -- Others -- Cellular Processes -- Cell Cycle -- Cell Death -- Cell Metabolism -- Vesicle Trafficking -- Endocytosis -- Exocytosis -- Gene Regulation/Expression |
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Transcription (Nucleus) -- Translation (Cytoplasm) -- Control of Gene Expression and Epigenetics -- Signal Transduction -- DNA Damage and Repair -- Nucleotide Excision Repair -- Homologous Recombination (HR) and Non-Homologous End Joining (NHEJ) -- DNA Mismatch Repair (MMR) -- Migration/Movement -- Intracellular Connections/Cell Adhesion -- Cadherins -- Desmosomal Junctions -- Tight Junctions -- Gap Junctions -- Immunology -- Inflammation -- Innate Immunity -- Acquired/Adaptive Immunity -- Immune Checkpoints -- Recommended Reading -- 2. Genetics -- Chromosomes -- Chromosomes Abnormality |
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Numerical Abnormality -- Chromosomal Rearrangements -- Gene Expression -- Patterns of Inheritance -- Autosomal Dominant Inheritance -- Autosomal Recessive Inheritance -- X-Linked -- Y-Linked -- Mitochondrial Inheritance -- Recommended Reading -- 3. Oncogenesis and Metastasis -- Oncogenesis -- Cancer -- Clinical Relevance of Cancer Cells Characteristics: Precursor Lesions -- Cell Populations and Stroma -- Invasion and Metastasis -- The Cell Cycle -- Cell Cycle -- Checkpoints -- Cyclins and Cyclin-Dependent Kinases (CDKs) -- Tumour Protein (TP53) -- Growth Factors and Signalling Pathways |
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Signalling -- Immortality and Quiescence -- Retinoblastoma 1 (RB1) -- Telomerase and the Hayflick Limit -- Cell Death -- Apoptosis -- Autophagy (Autophagocytosis) -- Clinical Relevance of Triggering Cell Death -- Oncogenesis is a Step-Wise Process -- Cancer Genes -- Tumour Suppressor Genes (TSG) -- Clinical Relevance of Tumour Suppressor Gene Activation -- Oncogenes -- Hallmarks of Cancer -- Enabling Hallmarks -- Emerging Hallmarks -- Recommended Reading -- 4. Microbiology -- Classification of Bacteria -- Bacteria Structure -- Infection in the Catheterised Patients |
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Appropriate Microbiology Tests -- Urine 'Dipstick' Testing -- Urine Cultures -- Polymerase Chain Reaction (PCR) -- Recommended Reading -- 5. Transplantation -- Self Versus Non-Self: The Relevance to Clinical Transplantation -- Blood Groups -- Major Histocompatibility Complex/Human Leucocyte Antigen -- Syngeneic Versus Allogeneic -- Clinical Transplantation (or Tissue-Typing) Laboratory -- Kidney Donor Types -- Living Donation -- Deceased Donation -- Donation after brain death -- Donation after circulatory death -- Ischaemic Reperfusion Injury (IRI) -- Basic Immunology -- Antigen Presentation |
| Notes |
Description based upon print version of record |
|
T-Cell Activation |
| Form |
Electronic book
|
| Author |
Osman, Nadir
|
|
Catto, James
|
|
Chapple, Christopher
|
| ISBN |
9781000378702 |
|
1000378705 |
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