| Description |
1 online resource (1 volume) : illustrations (some color) |
| Series |
Translational Epigenetics ; volume 29 |
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Translational epigenetics series ; v. 29.
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| Contents |
Intro -- Medical Epigenetics -- Copyright -- Contents -- Contributors -- Preface -- Section A Overview -- Chapter 1 Advances in medical epigenetics -- Introduction -- Basic principles of epigenetics -- General medical aspects of epigenetics -- Epigenetics of system disorders -- Multisystem medical epigenetics -- Bioinformatics of epigenetic medicine -- Pharmacology of epigenetics -- Therapeutic epigenetics -- Medical epigenetics: Future prospects -- Conclusion -- References -- Section B General medical aspects of epigenetics -- Chapter 2 Environmental epigenetic epidemiology -- Introduction -- Malnutrition -- Environmental pollutants -- Air pollution -- Endocrine-disrupting chemicals -- Heavy metals -- Substance abuse -- Alcohol -- Tobacco smoking -- Marijuana smoking -- Opioids -- Infection -- Conclusions and perspectives -- Acknowledgment -- References -- Chapter 3 Lifestyle and preventive medical epigenetics -- Introduction -- Epigenetics -- How epigenetics influence risk of diseases -- How lifestyle determines epigenetics -- How knowledge on epigenetics could be used to prevent diseases -- Impact of dietary pattern on the epigenome -- Carbohydrates and epigenetic modifications -- Proteins and epigenetic modifications -- Fatty acids and epigenetic modifications -- Role of micronutrients in epigenetics -- Essential vitamins -- Mineral elements -- Bioactive compounds -- Exercise and epigenetics -- Environmental factors and epigenetic modification -- Lifestyle modification as a preventive tool for medical epigenetics -- Conclusion -- References -- Chapter 4 Environmental medical epigenetics: A review of epigenetically induced medical risks generated from exposures in our air, f ... -- Introduction -- Allergens -- Aeroallergens -- Food allergens -- Secondhand cigarette smoke and vaping -- Traffic-related air pollution -- PM 2.5 |
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Diesel exhaust particles -- Polycyclic aromatic hydrocarbons -- Trace metals -- Heavy metals -- Chromium -- Arsenic -- Lead -- Cadmium -- Endocrine-disrupting chemicals -- Bisphenol A -- Phthalates -- Parabens -- Flame retardants/polybrominated diphenyl ethers -- Pesticides and fungicides -- Vinclozolin -- Persistent organic pollutants and other pesticides -- Volatile organic compounds -- Farm exposure -- Diet -- Folic acid and other methyl donors -- Additional vitamin and antioxidant supplementation -- Dietary fat, sucrose -- Famine -- Conclusions/outstanding questions -- Glossary -- References -- Chapter 5 Behavioral medical epigenetics -- Introduction -- Impact of environmental factors on behavior -- Animal models and studies of human behavior -- Environmental stressors and epigenetic mediators of the stress response -- Nonepigenetic and alternate mechanisms of stress -- The HPA axis and the stress response -- Glucocorticoid signaling and epigenetics -- HPA axis genes: Genes that regulate glucocorticoid signaling -- Chronic stress and glucocorticoid resistance -- Glucocorticoid resistance and epigenetics -- HPA axis genes: Genes that regulate tissue-specific processes -- Environmental stressors and neurotransmitters -- Interconnectivity of the neurotransmitter systems -- The dopaminergic system -- Behavioral disorders associated with the dopaminergic system -- Evidence for glucocorticoid effect on dopaminergic transmission -- Glucocorticoids and dopamine in drug addiction -- Epigenetic mediators of glucocorticoids on dopamine-related behavior -- Adrenergic and noradrenergic systems -- Behavioral disorders associated with the adrenergic and noradrenergic system -- Evidence for glucocorticoid effect on adrenergic and noradrenergic transmission -- Epigenetic mediators of glucocorticoids on adrenaline- and noradrenaline-related behavior |
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The serotonergic (5-HT) system -- Behavioral disorders associated with the serotonergic system -- Evidence for glucocorticoid effect on serotonergic transmission -- Epigenetic mediators of glucocorticoids on serotonin-related behavior -- Glutamate and GABA systems -- Behavioral disorders associated with the glutamate and GABA system -- Evidence for glucocorticoid effect on glutamate and GABA system -- Epigenetic mediators of glucocorticoids on glutamate and GABA-related behavior -- Conclusion -- References -- Chapter 6 Medical epigenetics and twins -- Introduction -- Monogenic disorders: Twin studies and the epigenetics of imprinting disorders -- Twin studies and Beckwith-Wiedemann syndrome -- Twin studies and Silver-Russell syndrome -- Twin studies and the epigenetics of multifactorial disorders -- Twin studies and the epigenetics of cardiovascular diseases -- Twin studies and the epigenetics of psychiatric disorders -- Twin studies and the epigenetics of autism -- Twin studies and the epigenetics of schizophrenia -- Twin studies and the epigenetics of depression -- Twin studies and the epigenetics of aging -- Twin studies and the epigenetics of metabolic traits and disease -- Body mass index -- Diabetes -- Twin studies and epigenetic mechanisms -- Rett syndrome -- Caveats -- Future directions -- Conclusions -- References -- Chapter 7 Epigenetic biomarkers of disease -- Introduction -- Epigenetic biomarkers -- Disruption of the "epigenetic machinery" in cancer -- Epigenetic mechanisms of acquired drug resistance -- Types of epigenetic modifications -- DNA methylation -- Noncoding RNAs (miRNAs) -- Histone modifications -- Chromatin remodeling -- Epigenetic biomarkers in cancer -- Diagnosis, prognosis, and drug response epigenetic biomarkers in solid biopsies -- Lung cancer -- Breast cancer -- Colorectal cancer -- Prostate cancer |
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Diagnosis, prognosis, and drug response biomarkers in liquid biopsies -- Lung cancer -- Breast cancer -- Colorectal cancer -- Prostate cancer -- Head and neck squamous cell carcinoma -- Pancreatic cancer -- Melanoma -- Hepatocellular carcinoma -- Methods for assessing epigenetic changes for biomarkers -- Genome-wide epigenetic analysis -- Enrichment-based methods -- Bisulfite conversion-based methods -- Specific methods for 5hmC -- miRNA genome-wide profiling -- Locus-specific epigenetic analysis -- Pyrosequencing -- Targeted next-generation sequencing -- Amplicon melting-based method -- RT-PCR based for 5mC and 5hmC targeted screening -- Specific methods for liquid biopsy -- Bioinformatic analysis -- Clinical application of epigenetic biomarkers -- Epigenetic biomarkers in precision medicine -- Epigenetic plasticity as a therapeutic target -- Epigenomic modulation drugs -- Future perspectives -- Conclusion -- References -- Chapter 8 Prognostic epigenetics -- Introduction -- DNA methylation markers of cancer prognosis -- Histone modifications as markers of cancer prognosis -- Noncoding RNA prognostic markers in cancer -- Prognostic epigenetic markers in nonmalignant pathology -- The future -- Conflict of interest statement -- References -- Section C Epigenetics of system disorders -- Chapter 9 Autoimmune disease and epigenetics -- Autoimmune disease overview -- Autoimmune disease etiology -- Epigenetics and autoimmunity -- Epigenetic regulation of T cell subset differentiation -- DNA methylation and autoimmune disease -- DNA hypomethylation -- DNA hypermethylation -- DNA hydroxymethylation -- Histone modifications and autoimmune disease -- Histone acetylation -- Histone methylation -- RNA modifications in autoimmune disease -- Environmental epigenetics -- Environmental epigenetics and autoimmunity -- Xenobiotics and autoimmunity |
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Mechanisms of xenobiotic-induced autoimmunity -- Xenobiotic-induced epigenetic changes and autoimmunity -- Trichloroethylene -- Trichloroethylene-mediated immunotoxicity -- Trichloroethylene and autoimmunity -- Trichloroethylene-induced autoimmunity in experimental models -- Trichloroethylene-mediated epigenetic changes in CD4 + T cells -- Conclusions -- References -- Chapter 10 Epigenetics of pulmonary diseases -- Introduction -- Epigenetic basics -- Epigenetics in disease -- Epigenetics in the lungs -- Epigenetics in pulmonary diseases -- Lung cancer -- Pulmonary hypertension -- Chronic obstructive pulmonary disease -- Idiopathic pulmonary fibrosis -- Tuberculosis -- Conclusion -- Grants -- Disclosures -- Author contributions -- References -- Chapter 11 Cardiovascular disorders and epigenetics -- Introduction -- Early heart development and the fetal origin of cardiovascular disease -- Epigenetic involvement in cardiovascular risk factors -- Smoking -- Age -- Hypertension -- Obesity and dyslipidemia -- Diabetes -- Epigenetics and cardiovascular disease -- Endothelial dysfunction and atherosclerosis -- Ischemic heart disease -- Stroke -- Vascular disease -- Cardiac hypertrophy -- Heart failure -- Epigenetic-based cardiovascular therapy -- Conclusion -- References -- Chapter 12 Epigenomics of intestinal disease -- Introduction -- Epigenetics and intestinal development -- Intestinal homeostasis and the microbiota -- Epigenetics, intestinal homeostasis, and the microbiota -- Microbiota-derived metabolites -- Diet and the intestinal epigenome -- Colon cancer -- Inflammatory bowel disease -- Irritable bowel syndrome -- Celiac disease -- Therapeutics -- Future directions -- Glossary -- Acknowledgments -- References -- Chapter 13 Epigenetics of skin disorders -- Immunologic skin diseases -- Introduction -- Epigenetics in systemic lupus erythematosus |
| Notes |
Print version record |
| Subject |
Medical genetics.
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Epigenetics.
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Genetics, Medical
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Epigenomics
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Epigenetics
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Medical genetics
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| Form |
Electronic book
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| Author |
Tollefsbol, Trygve O., editor.
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| ISBN |
0128243260 |
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9780128243268 |
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