| Description |
1 online resource (340 p.) |
| Contents |
Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Chapter 1. Historical Overview of Endocrinology, Neurology and Immunology -- 1.1. The history of endocrinology -- 1.2. The history of neurology -- 1.3. The history of immunology -- Chapter 2. Regulatory Systems Integrating External and Internal Changes -- 2.1. Regulatory systems: endocrine, nervous and immune -- 2.1.1. Endocrine system -- 2.1.2. Nervous system -- 2.1.3. Immune system -- 2.2. Origin and diversity of signals and communication modes -- 2.2.1. Origin -- 2.2.2. Diversity -- 2.2.3. Communication modes |
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2.3. Integration of extracellular signals: plasma membrane receptors -- 2.3.1. Chemical signals and mechanisms of action: receptor types and signaling modulation -- 2.3.2. Integration of multiple signal inputs: ratio of stimulatory vs inhibitory signals -- 2.3.3. Physical signals -- 2.4. Nuclear receptors -- 2.4.1. Chemical nature of signals and functional characteristics of nuclear receptors -- 2.4.2. Molecular mechanisms underlying regulation of gene transcription -- Chapter 3. Intracellular Events in Response to Signals -- 3.1. Signaling pathways -- 3.1.1. General overview |
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3.1.2. Signal termination -- 3.1.3. Control of protein activities: allostery, covalent modifications and proteolytic cleavage -- 3.1.4. Impaired cellular responses to extracellular signals -- 3.1.5. Subcellular localization and sequestration -- 3.1.6. Crosstalk -- 3.2. Sensing of extracellular and intracellular cues -- 3.2.1. Sensing of extracellular cues -- 3.2.2. Sensing of intracellular cues -- 3.3. Functional diversity of proteins -- 3.3.1. Multifaceted "master regulators" -- 3.3.2. Molecular motor proteins -- 3.3.3. Interactional domains -- 3.3.4. Carrier proteins -- 3.3.5. Decoy molecules |
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3.3.6. Heat shock proteins as molecular chaperones -- 3.3.7. Hormone-like peptides: molecular mimicry -- 3.3.8. Telomerase and integrity of linear chromosomes -- Chapter 4. Integrative Aspects: From Cellular to Whole-Body Level -- 4.1. Homeostasis equilibrium: dynamic steady state -- 4.1.1. Regulation of systemic glucose homeostasis -- 4.1.2. Tissue homeostasis -- 4.1.3. Muscle and bone mass homeostasis -- 4.1.4. Whole-body energy homeostasis -- 4.1.5. Metabolism and cellular energy homeostasis -- 4.1.6. The gut microbiome and glucose homeostasis -- 4.1.7. Synaptic homeostasis |
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4.1.8. Open issues: membrane lipid homeostasis and acid-base homeostasis -- 4.2. Homeostasis disruption -- 4.2.1. Endocrine disorders: excess or impaired hormone secretion -- 4.2.2. Muscle energy wasting -- 4.2.3. Energy -- 4.2.4. Cell number and activity -- 4.3. Crosstalk between organs, tissues and regulatory systems -- 4.3.1. Axis concept -- 4.3.2. Crosstalk between neuroendocrine axes -- 4.3.3. Crosstalks between organs and brain -- 4.3.4. Crosstalk between immune, endocrine and nervous systems -- 4.3.5. Immune system and cancer cell interactions |
| Notes |
Description based upon print version of record |
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4.3.6. Adjustments of intermediary metabolism: brain, skeletal muscle, cancer cells |
| Form |
Electronic book
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| Author |
Pirkmajer, Sergej
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| ISBN |
9781394236305 |
|
1394236301 |
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