| Description |
1 online resource (388 pages) |
| Contents |
Cover; Half title; Title Page; Copyright; Contents; Preface; Editor Bios; Contributors; Section I: Health Issues Associated with Dietary Phosphorus Intake; Chapter 1: Overview of Chronic Health Risks Associated with Phosphorus Excess; Abstract; Bullet Points; 1.1 Introduction; 1.2 Chronic Health Risks Associated with Phosphorus Excess; 1.2.1 Progression of Chronic Kidney Disease; 1.2.2 Mineral Bone Disease and Soft Tissue Calcifications; 1.2.3 Cardiovascular Disease; 1.2.4 Mortality; 1.2.5 Increased Anemia Risk; 1.2.6 Increased Cancer Risk; 1.3 Conclusions; References |
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Chapter 2: Preclinical Evidence of the Nonskeletal Adverse Health Effects of High Dietary PhosphorusAbstract; Bullet Points; 2.1 Cancer, Diet, and Phosphorus Consumption; 2.1.1 The Significance of Diet to Cancer; 2.1.2 Dietary Inorganic Phosphate and Cancer; 2.1.3 Preclinical Models of Cancer; 2.2 Preclinical Evidence for a Modulating Effect of Phosphorus Consumption on Cancer; 2.2.1 Cell-Based Models Identify Increased Pi Availability as a Risk Factor for Cancer; 2.2.2 Dietary Pi Consumption and Carcinogen-Induced Skin Cancer; 2.2.3 Dietary Pi Consumption and Oncogene-Induced Lung Cancer |
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2.2.4 Relevance to Humans2.2.5 Dietary Pi as a Modulator of Cancer Initiation and Progression; 2.3 Cell Autonomous Effects of Phosphorus Availability on Cell Growth and Transformation; 2.3.1 Pi Availability and Cell Growth; 2.3.2 Increased Pi Availability Alters the Cellular and Molecular Phenotype; 2.3.3 Cell Transport and Sensing of Pi; 2.3.4 Slc20a1 and Cell Proliferation; 2.3.5 Slc34a2: A Novel Cancer Therapeutic Target; 2.4 Phosphorus-Responsive Endocrine, Paracrine, and Autocrine Factors and Cancer; 2.4.1 Dietary Pi-Responsive Endocrine Factors; 2.4.2 Vitamin D; 2.4.3 FGF23 |
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2.4.4 Klotho2.4.5 Osteopontin; 2.5 Conclusions; Acknowledgments; References; Chapter 3: Clinical and Preclinical Evidence of the Skeletal and Vascular Adverse Health Effects of High Dietary Phosphorus; Abstract; Bullet Points; 3.1 Introduction; 3.2 Pathophysiology of Vascular Calcification; 3.2.1 Role of Phosphorus; 3.2.2 Role of PTH and Other Factors; 3.3 Pathophysiology of Bone Fragility in CKD; 3.3.1 Role of Phosphorus; 3.3.2 Role of PTH and Other Factors; 3.4 Vascular Calcification, Bone Health, and Survival: Lessons from Clinical and Preclinical Evidence; 3.4.1 Clinical Evidence |
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3.4.2 Preclinical Evidence3.5 Areas for Future Research; 3.6 Conclusions; References; Chapter 4: Associations between Phosphorus Intake and Mortality; Abstract; Bullet Points; 4.1 Introduction; 4.2 Phosphate Homeostasis in Humans: Nutritional Intake, Intestinal Absorption, and Renal Excretion; 4.3 Assessing Nutritional P Intake and P Balance: A Tough Goal in Research and Clinical Practice; 4.4 Phosphate and Mortality: Mechanisms; 4.5 Phosphate Intake and Mortality: Observational Studies; 4.6 Conclusions; References; Chapter 5: Phosphorus Intake and Whole-Body Phosphorus Homeostasis; Abstract |
| Notes |
Bullet Points |
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Print version record |
| Form |
Electronic book
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| Author |
Calvo, Mona S
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| ISBN |
9781351645843 |
|
1351645846 |
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