Title Tumor models in cancer research / Beverly A. Teicher, editor

Edition 2nd ed Published New York : Humana Press : Springer, ©2011

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Description 1 online resource (xiv, 693 pages) : illustrations (some color) Series Cancer drug discovery and development Cancer drug discovery and development Contents Perspectives on the history and evolution of tumor models -- Murine L1210 and P388 leukemias -- Transplantable syngeneic rodent tumors: solid tumors in mice -- B16 murine melanoma: historical perspective on the development of a solid tumor model -- Human tumor xenograft efficacy models -- Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time -- Patient-derived tumor models and explants -- The pediatric preclinical testing program -- Imaging efficacy in tumor models -- Mammary cancer in rats -- Animal models of melanoma -- Experimental animal models for investigating renal cell carcinoma pathogenesis and preclinical therapeutic approaches -- Animal models of mesothelioma -- The use of mouse models to study leukemia/lymphoma and assess therapeutic approaches -- Spontaneous companion animal (pet) cancers -- Genetically engineered mouse models of pancreatic ductal adenocarcinoma -- Transgenic adenocarcinoma of the mouse prostate: a validated model for the identification and characterization of molecular targets and the evaluation of therapeutic agents -- The utility of transgenic mouse models for cancer prevention research -- Models for evaluation of targeted therapies of invasive and metastatic disease -- Animal models of toxicities caused by anti-neoplastic therapy -- Bone marrow as a critical normal tissue that limits drug dose/exposure in preclinical models and the clinic -- Anesthetic considerations for the study of murine tumor models -- Preclinical tumor response end points -- Tumor cell survival -- Apoptosis in vivo -- Transparent window models and intravital microscopy: imaging gene expression, physiological function and therapeutic effects in tumors Summary Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research 2nd edition, provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results Analysis neoplasms farmacologie pharmacology toxicologie toxicology biomedische wetenschappen biomedicine Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes Print version record Subject Tumors -- Animal models Cancer cells. Oncology, Experimental. Biological models. Diseases -- Animal models. Mice. Neoplasms -- drug therapy Models, Biological Disease Models, Animal Drug Evaluation, Preclinical Antineoplastic Agents -- pharmacology Animals Mice Neoplasms, Experimental HEALTH & FITNESS -- Diseases -- Cancer. MEDICAL -- Oncology. Médecine. Mice Diseases -- Animal models Biological models Cancer cells Oncology, Experimental Tumors -- Animal models Form Electronic book Author Teicher, Beverly A., 1952- ISBN 9781607619680 1607619687

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