Title Myelodysplastic syndromes (MDS) : risk factors, treatment and prognosis / Deanna Rodgers, editor

Published New York : Nova Biomedical, [2016]

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Description 1 online resource Series Recent advances in hematology research Recent advances in hematology research series. Contents MYELODYSPLASTIC SYNDROMES (MDS) RISK FACTORS, TREATMENT AND PROGNOSIS ; MYELODYSPLASTIC SYNDROMES (MDS) RISK FACTORS, TREATMENT AND PROGNOSIS ; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE ; Chapter 1 FROM RISK FACTORS TO PROGNOSIS IN MYELODYSPLASIC SYNDROMES: THE ROLE OF GENETIC VARIANCE ; ABSTRACT ; DEFINITION AND EPIDEMIOLOGY ; ETIOLOGY AND RISK FACTORS ; PATHOPHYSIOLOGY; DIAGNOSIS, CLASSIFICATION AND PROGNOSTIC FACTORS ; TREATMENT ; PROGNOSIS ; REFERENCES ; Chapter 2 THE INFLAMMATORY AND AUTOIMMUNE NATURE OF MYELODYSPLASTIC SYNDROMES ; ABSTRACT INTRODUCTIONTHE ASSOCIATION BETWEEN AUTOIMMUNE DISEASES AND MYELODYSPLASTIC SYNDROMES; T-CELL AND B-CELL ABNORMALITIES IN MDS ; THE INVOLVEMENT OF REGULATORY T-CELLS (TREG) IN THE MDS PATHOGENESIS; NATURAL KILLER CELLS IN MDS ; ABNORMAL LEVELS OF INFLAMMATORY CYTOKINES AND CHEMOKINES IN THE PEREIPHERAL BLOOD AND BONE MARROW OF MDS PATIENTS; TOLL-LIKE RECEPTOR SIGNALING AND ITS ACTIVATION IN MDS ; BONE MARROW NICHE AND ITS INVOLVEMENT IN MDS; INDUCTION OF MYELODYSPLASIA BY MYELOID-DERIVED SUPPRESSOR CELLS ; ANTI-INNATE IMMUNE THERAPIES IN MDS ; CONCLUSION AND PERSPECTIVES ACKNOWLEDGMENTS REFERENCES ; Chapter 3 PATHOGENESIS OF 5q- SYNDROME ; ABSTRACT ; INTRODUCTION ; THE POSSIBLE ROLE OF CANDIDATE GENES FROM CDR IN 5q- SYNDROME ; Role of SPARC in 5q- Syndrome ; RPS14 and Ribosomopathies ; The Role of miR-145 and miR-146a in the 5q- Syndrome ; The Importance of p53 in the Molecular Mechanism of 5q- Syndrome ; Activation of p53 by Ribosome Dysfunction in Model Systems ; Activation of p53 and up-Regulation of the p53 Pathway in 5q- Syndrome ; The Relation between p53 and miR145 ; ROLE OF FURTHER GENES IN 5q- SYNDROME The Role of Genes Positioned on 5q Chromosome The Role of Genes Not Positioned on Chromosome 5 ; Therapy of 5q- Syndrome ; CONCLUSION AND PERSPECTIVES; ACKNOWLEDGMENTS ; REFERENCES ; Chapter 4 GENETIC MUTATIONS IDENTIFIED IN MYELODYSPLASTIC SYNDROMES AND THEIR SIGNIFICANCE ; ABSTRACT; INTRODUCTION; MUTATIONS IN EPIGENETIC REGULATORS IN MDS; MUTATIONS OF THE DNMT3A GENE ; MUTATIONS OF THE TET2 GENE ; MUTATIONS OF THE IDH1 AND IDH2 GENES ; MUTATIONS OF THE EZH2 GENE; MUTATIONS OF THE UTX GENE ; MUTATIONS OF THE ASXL1 GENE ; MUTATIONS OF THE C-CBL GENE ; RUNX1 MUTATIONS RAS MUTATIONS IN MDS TP53 MUTATIONS ; MUTATIONS IN RNA SPLICING MACHINERY ; MUTATIONS IN OTHER GENES IN MDS PATIENTS ; CONCLUSION AND PERSPECTIVES ; ACKNOWLEDGMENTS; REFERENCES ; Chapter 5 RISK FACTORS AND PROGNOSTIC SCORING SYSTEMS IN ARGENTINEAN PATIENTS WITH MDS: A MULTICENTRIC STUDY; ABSTRACT ; INTRODUCTION ; PROGNOSTIC FACTORS; BM Blasts and Cellular Morphology ; Cytogenetics ; Cytopenias ; Transfusion Dependency ; SCORING SYSTEMS ; International Prognostic Scoring System (IPSS) ; WHO CLASSIFICATION-BASED PROGNOSTIC SCORING SYSTEM (WPSS) Bibliography Includes bibliographical references and index Notes Description based on print version record Subject Myelodysplastic syndromes -- Treatment Myelodysplastic syndromes -- Research Myelodysplastic syndromes. Myelodysplastic Syndromes HEALTH & FITNESS / Diseases / General MEDICAL / Clinical Medicine MEDICAL / Diseases MEDICAL / Evidence-Based Medicine MEDICAL / Internal Medicine Myelodysplastic syndromes Form Electronic book Author Rodgers, Deanna, editor LC no. 2020679599 ISBN 9781634843300 1634843304

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