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E-book

Title Principles of molecular medicine / edited by Marschall S. Runge, Cam Patterson ; foreword by Victor A. Mckusick
Edition Second edition
Published Totowa, N.J. : Humana Press, [2006]
©2006
Online access available from:
Springer eBooks    View Resource Record  

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Description 1 online resource (xxv, 1268 pages, 8 unnumbered pages of plates) : illustrations (some color), color map
Contents Axonal regeneration and recovery from chronic central nervous system injury / Stephen M. Strittmatter -- XIV. Psychiatry / Kerry J. Ressler and Charles B. Nemeroff. Molecular mechanisms regulating behavior: focus on genetic and environmental influences / Kerry J. Ressler and Charles B. Nemeroff -- The complex genetics of psychiatric disorders / Ming T. Tsuang, Stephen J. Glatt, and Stephen V. Faraone -- Treating depression: antidepressant-activated signaling pathways as a source for novel drug targets / Marcelo Páez-Pereda and Florian Holsboer -- Anxiety disorders / Gregory M. Sullivan and Jack M. Gorman -- Trauma spectrum disorders / christine Heim, J. Douglas Bremner, and Charles B. Nemeroff -- Schizophrenia / Carol A. Tamminga, Deborah C. Medoff, and Gunvant Thaker -- Disorders of substance abuse and dependence / Eric J. Nestler and Jennifer Chao -- Autism and related disorders / Linmarie Sikich [and others]
Cardiac hypertrophy / Thomas force and Jeffrey D. Molkentin -- Arrhythmias / Barry London -- Genomics / Calum A. MacRae and Christopher J. O'Donnell -- Cardiovascular gene therapy / David A. Dichek -- III. Pulmonary diseases / Richard C. Boucher and Pedar G. Noone. Idiopathic interstitial pneumonias / Talmadge E. King, Jr. -- Asthma / Stephen T. Holgate, Gordon Dent, and Mark G. Buckley -- Pulmonary emphysema / Steven D. Shapiro -- Pulmonary hypertension / Brian Fouty and David M. Rodman -- Acute lung injury / David C. Christiani and Michelle Ng Gong -- Primary ciliary dyskinesia / Peadar G. Noone, Maimoona Zariwala, and Michael R. Knowles -- Cystic fibrosis / Scott H. Donaldson and Richard C. Boucher -- Gene therapy for lung diseases / Jane C. Davies, Duncan M. Geddes, and Eric W.F.W. Alton -- Sarcoidosis / Kelly D. Chason and Stephen L. Tilley -- Disorders of pulmonary surfactant homeostasis / Jeffrey A. Whitsett, Susan E. Wert, and Bruce C. Trapnell -- IV. Endocrinology / Michael J. McPhaul. Mechanisms of hormone action / Stephen R. Hammes, Carol A. Lange, and Michael J. McPaul -- Diabetes mellitus / William L. Lowe, Jr. -- Pituitary function and neoplasia / Shlomo Melmed-- Growth hormone deficiency disorders / Amy Potter and John A. Phillips, III
I. Genetics / Terry Magnuson and James P. Evans. Mendelian inheritance / Bruce R. Korf -- Nontraditional inheritance / Shawn E. McCandless and Suzanne B. Cassidy -- Identifying causal genetic factors / Christopher I. Amos, John S. Witte, and William G. Neuman -- Cancer genetics and molecular oncology / Sharon E. Plon -- Pharmacogenetics / Renee E. Edkins and Dennis J. Cheek -- Hemophilia as a model disease for gene therapy of genetic disorders / Jay Lozier -- Genetic counseling / Robin L. Bennett -- Animal models in biomedical research: ethics, challenges, and opportunities / Robert W. Williams -- Ethical, legal, and social implications / Marcia Van Riper -- II. Cardiology / Anthony Rosenzweig. Congenital heart disease / Lazaros K. Kochilas and Alvin J. Chin -- Inherited cardiomyopathies / Carolyn Y. Ho and Christine E. Seidman -- -- Heart failure: emerging concepts in excitation-contraction coupling and [beta]-adrenoceptor coupling / Clive J. Lewis [and others] -- Aortic diseases / Saumya Das, James L. Januzzi, Jr., and Eric M. Isselbacher -- Atherosclerotic coronary disease / Robert e. Gerszten and Antony Rosenzweig -- Lipid metabolism and coronary artery disease / Mason W. Freeman -- Hypertension / Khurshed A. Katki and Donald J. DiPette
Multiple myeloma: a story of genes and the environment / Kenneth H. Shain and William S. Dalton -- HIV-1, AIDS, and related malignancies / Maureen M. Goodenow and James J. Kohler -- X. Hematology / Swee Lay Thein. Disorders of the red cell membrane / Jean Delaunay and Gordon W. Stewart -- Paroxysmal nocturnal hemoglobinuria / Bruno Rotoli, Khedoudja Nafa, and Antonio M. Risitano -- Iron metabolism / Nancy C. Andrews -- Correction of genetic blood defects by gene transfer / Marina Cavazzana-Calvo [and others] -- Bone marrow failures syndromes / J. Eric Turner and Thomas C. Shea -- Coagulation disorders / Stephan Moll and Gilbert C. White II -- Advances in transfusion safety / Lorna M. Williamson and Jean-Pierre Allain -- XI. Immunology and infectious diseases / Steven M. Holland. Immunomodulation / Juan C. Gea-Banacloche -- HIV molecular biology, treatment, and resistance / Frank Maldarelli -- Cellular and molecular aspects of pneumonia / Marcus J. Schultz and Tom van der Poll -- Molecular pathogenesis of fungal infections / Brahm H. Segal -- XII. Dermatology / Luis A. Diaz and Lowell A. Goldsmith. Psoriasis / James T. Elder -- Atopic dermatitis / Kefei Kang, Donald Y.M. Leung, and Kevin D. Cooper
Pemphigus foliaceus, pemphigus vulgaris, paraneoplastic pemphigus, bullous pemphigoid, herpes gestationis and cicatricial pemphigoid / Ning Li [and others] -- Systemic lupus erythematosus / Amr H. Sawalha, Luis A. Diaz, and John B. Harley -- Systemic sclerosis / Chris T. Derk and Sergio A. Jimenez -- Diseases with signaling and transcriptional abnormalities / David S. Rubenstein, Amy Stein, and Lowell A. Goldsmith -- Genetic skin diseases with neoplasia / David S. Rubenstein -- Melanoma and nevi / Nancy E. Thomas -- Disorders of hypopigmentation / Julie V. Schaffer and Jean L. Bolognia -- Epidermolysis bullosa / Jouni Uitto, Gabriele Richard, and Angela M. Christiano -- Connective tissue disorders: the paradigms of Ehlers-Danlos syndrome and pseudoxanthoma elasticum / Jouni Uitto and Franziska Ringpfeil -- Genetic epidermal diseases / Amy Stein and Lowell A. Goldsmith -- Genetic hair and nail defects / Marija Tadin-Strapps and Angela M. Christiano -- Metabolic genetic disorders with prominent skin findings / Christopher B. Mizelle and Lowell A. Goldsmith -- Heritable conditions affecting tissues of the oral cavity / J. Tim Wright
Skeletal muscle structure and function / Elizabeth M. McNally, Karen A. Lapidos, and Matthew T. Wheeler -- Stem cells and muscle regeneration / Cindy M. Martin, Thomas J. Hawke, and Daniel J. Garry -- Skeletal muscle hypertrophy and response to training / Zhen Yan and R. Sanders Williams -- Muscular dystrophies: mechanisms / Peter B. Kang and Louis M. Kunkel -- Rhabdomyosarcomas / Stephen J. Tapscott -- IX. Oncology / W. Stratford May, Jr. Apoptosis / W. Stratford May, Jr. and Xingming Deng -- Colorectal cancer / Satya Narayan -- Breast cancer / Yi Huang and Nancy E. Davidson -- Lung cancer / Lei Xiao -- Discoveries and frontiers in prostate cancer translational sciences / Jonathan W. Simons -- Cutaneous melanoma / Moira R. Jackson and Stephen P. Sugrue -- Applications of gene expression profiling to the study of malignant gliomas / Anthony T. Yachnis and Henry V. Baker -- Acute myeloid leukemias / Iris T. Chan and D. Gary Gilliland -- Acute lymphoblastic leukemia / Alexander E. Perl and Donald Small -- Chronic myelogenous leukemia / Brian J. Druker -- Non-Hodgkin's lymphoma and chronic lymphocytic leukemia / Ayad M. Al-Katib and Anwar N. Mohamed
Thyroid disorders / Peter Kopp -- Disorders of the parathyroid gland / Andrew Arnold and Michael A. Levine -- Congenital adrenal hyperplasia / Robert C. Wilson and Maria I. New -- Adrenal diseases / Richard J. Auchus, William E. Rainey, and Keith L. Parker -- Multiple endocrine neoplasia type 1 / Rajesh V. Thakker -- Multiple endocrine neoplasia type 2 / Robert F. Gagel [and others] -- Disorders of sex determination and differentiation / Charmian A. Quigley -- Sex chromosome disorders / Andrew R. Zinn -- Disorders of pubertal development / Tomonobu Hasegawa -- Defects of androgen action / Michael J. McPaul -- Molecular endocrinology of the testis / Marco Marcelli [and others] -- Ovarian diseases / Elizabeth M. McGee and Tammy L. Loucks -- V. Metabolic disorders / Samuel Klein. Gastrointestinal regulation of food intake / Patrick Tso and Min Liu -- Cellular regulation of lipolysis / Allan Green -- Fat-induced insulin resistance and atherosclerosis / Guenther Boden -- Metabolic and molecular aspects of sarcopenia / W. Todd Cade and Kevin E. Yarasheski -- Adipose tissue development and metabolism / Sheila Collins, Yushi Bai, and Jacques Robidoux
VI. Gastroenterology / David A. Brenner. Hepatitis C / Johnson Yiu-Nam Lau [and others] -- Molecular diagnostics in hepatitis B / Scott Bowden and Stehen Locarnini -- Hereditary hemochromatosis / francesca Ferrara, Elena Corradini, and Antonello Pietrangelo -- Pancreatic exocrine dysfunction / David C. Whitcomb and Jonathan A. Cohn -- Small and large bowel dysfunction / Deborah C. Rubin -- the molecular mechanisms of Helicobacter pylori-associated gastroduodenal disease / Peter B. Ernst -- VII. Nephrology / William E. Mitch. Nitric oxide synthase and cyclooxygenase in the kidneys / Christopher S. Wilcox -- Hypertension and socium channel turnover / Douglas C. Eaton, Bela Malik, and He-Ping Ma -- Nephrogenic diabetes insipidus: water and urea transport / Jeff M. sands and Daniel G. Bichet -- Glomerulonephritis and smad signaling / Hui Y. Lan and Richard J. Johnson -- Interstiial nephritis / Carla Zoja and Giuseppe Remuzzi -- The pathophysiology of acute renal failure / Didier Portilla [and others] -- Loss of lean body mass in uremia / S. Russ Price and William E. Mitch -- Mechanisms of renal allograft rejection / Daniel R. Goldstein, Anirban Bose, and Fadi G. Lakkis -- VIII. Musculoskeletal / Daniel J. Garry. Muscle development and differentiation / Eric N. Olson
XII. Neurology / Stephen M. Strittmatter. The genetic basis of human cerebral cortical malformations / Bernard S. Chang and Christopher A. Walsh -- Muscular dystrophies: molecular diagnosis / Eric P. Hoffman and Erynn S. Gordon -- Channelopathies of the nervous system / Stephen C. Cannon -- Charcot-Marie-tooth disease and related peripheral neuropathies / James R. Lupski -- Amyotrophic lateral sclerosis and related motor neuron disorders: lessons in pathogenesis and therapy from genetics / Robert H. Brown, Jr. -- Trinucleotide repeat disorders / Huda Y. Zoghbi -- Parkinson's disease / Deepak M. Sampathu and Virginia M.-Y. Lee -- Genetics and neurobiology of Alzheimer's disease and frontotemporal dementias / Peter H. St. George-Hyslop -- Prion diseases / Adriano Aguzzi -- Narcolepsy and other neurological sleep disorders / Thomas E. Scammell -- Neurofibromatosis 1 and 2 / Gregory J. Esper and David H. Gutmann
Summary Overview of internal medicine, including recent discoveries in molecular medicine, and numerous applications
Bibliography Includes bibliographical references and index
Subject Medical genetics.
Molecular biology.
Pathology, Molecular.
Genetics, Medical.
Genetic Therapy.
Molecular Biology.
Form Electronic book
Author Patterson, Cam.
Runge, Marschall Stevens, 1954-
ISBN 1588292029 (alk. paper)
159259963X (electronic bk.)
9781588292025
9781592599639 (electronic bk.)