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E-book

Title Diagnosis, therapy, and prognosis / edited by M.A. Hayat
Published Dordrecht ; London : Springer, 2012
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Description 1 online resource : illustrations (some color)
Series Pediatric cancer ; v. 3
Pediatric cancer ; v. 3
Contents Part 1. Teratoid/Rhabdoid -- Early Childhood Atypical Teratoid/Rhabdoid Tumors / Christine Haberler and Irene Slavc -- Atypical Teratoid/Rhabdoid Tumors / Simone Treiger Sredni and Rishi R. Lulla -- Paediatric Teratoid/Rhabdoid Tumours: Germline Deletions of Chromosome 22q11.2 / Rachel Beddow -- Pediatric Atypical Teratoid/Rhabdoid Tumor: Role of INI1 Tumor Suppressor Gene / Mariela Carolina Coccé and Marta Susana Gallego -- Atypical Teratoid/Rhabdoid Tumors: Diagnosis Using Imaging / Atilla Arslanoglu -- Pediatric Atypical Teratoid/Rhabdoid Tumor in the Spine: Diagnosis and Treatment / Stella Stabouli -- Early Childhood Clival-C2 Atypical Teratoid/Rhabdoid Tumor: Gross Total Resection Followed by Aggressive Chemotherapy and Radiation / Michael J. Kramarz, Eric M. Jackson, Adam C. Resnick and Phillip B. Storm -- Pediatric Atypical Teratoid/Rhabdoid Tumors: Dissemination to the Cerebrospinal Fluid / Junjeong Choi, Hyosun Kim and Se Hoon Kim -- Part 2. Medulloblastoma -- Teratoid Pediatric Medullomyoblastoma / Uygur Er -- Pediatric Medulloblastoma: Mechanisms of Initiation and Progression / Wayne D. Thomas and Jinbiao Chen -- Medulloblastoma Initiation and Growth: Role of Hepatocyte Growth Factor / Daniel W. Fults -- Medulloblastoma -- Molecular Genetics / Esther Manor and Lipa Bodner -- Pediatric Medulloblastoma: The Role of Heterozygous Germ-Line Mutations in the NBN Gene / Krystyna H. Chrzanowska, Joanna Trubicka and Elżbieta Ciara -- Pediatric Medulloblastoma: Pituitary Adenylyl Cyclase Activating Peptide/Protein Kinase A Antagonism of Hedgehog Signaling / Joseph R. Cohen, Linda M. Liau and James A. Waschek -- Medulloblastoma: Role of MYCN Gene Amplification Using Fluorescence In Situ Hybridization and Real Time Quantitative PCR Methods / Cecilia Surace -- Pediatric Medulloblastoma: Ultrastructure / Gerhard Franz Walter and Douglas A. Weeks -- Pediatric Medullomyoblastoma: Immunohistochemical Analyses / Masaki Ueno, Masayuki Onodera, Takashi Kusaka, Reiji Haba and Takashi Tamiya, et al. -- Boost Gamma Knife Radiosurgery During Multimodality Management of Medulloblastoma/PNET Tumors / Thomas Flannery, Douglas Kondziolka and L. Dade Lunsford -- Early Childhood Medulloblastoma: Prognostic Factors / André O. von Bueren and Stefan Rutkowski -- Part 3. Retinoblastoma -- Trilateral Retinoblastoma: Diagnosis Using Magnetic Resonance Imaging / Elżbieta Jurkiewicz, Olga Rutynowska and Danuta Perek -- Pediatric Intraocular Retinoblastoma: Treatment / Parag K. Shah, Saurabh Aurora, V. Narendran and N. Kalpana -- Part 4. Glioma -- Pediatric High-Grade Glioma: Role of Microsatellite Instability / Marta Viana-Pereira, Chris Jones and Rui Manuel Reis -- Low-Grade Glioma in Children: Effects of Radiotherapy / Erin S. Murphy and Thomas E. Merchant -- Part 5. Spinal Tumors -- Pediatric Multiple Primary Cranio-Spinal Tumors Associated with Neurofibromatosis Type 2: Combined Therapeutical Strategies / Teresa Stachowicz-Stencel -- Pediatric Intradural Lipoma of the Cervicothoracic Spinal Cord: Laminectomy and Duraplasty / Ahmet Metin Şanlı, Hayri Kertmen and Bora Gürer -- Part 6. Miscellaneous Tumors -- Pediatric Embryonal Tumors: Prognostic Role of Cyclin A and B1 Proteins / George A. Alexiou, Kalliopi Stefanaki, Amalia Patereli and Neofytos Prodromou -- Intracranial Pediatric Ependymoma: Role of Cytogenetic Markers Using Comparative Genomic Hybridization and Fluorescent In Situ Hybridization / Annalisa Pezzolo -- Pediatric Hepatoblastoma. Complete Surgery and Ultrasound Monitoring / Daniela Iacob, Otilia Fufezan and Alexandru Serban -- Treatment of Pineal Region Tumors in Childhood / Ali Varan, Nejat Akalan and Faruk Zorlu -- Benign Testicular Tumors in Children: Testicular Preserving Surgery / Rajendra Nerli, Aseem Shukla and Murigendra Hiremath
Summary Brain tumors are the most common solid tumor of childhood as well as the leading cause of cancer-related mortality in children. This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. Now it has become possible to achieve the goal of targeting new, more effective therapies to minimize the tragedy faced by children. This research features the application of molecular genetics in combating atypical teratoid/rhabdoid tumor (AT/RT), a highly aggressive embryonal CNS tumor that is among the most common malignant neoplasms in children, with a peak occurrence in infants younger than three years old. Contributors also examine the reasons for the common misdiagnosis of AT/RT tumors as other types of CNS tumors. They help resolve this issue by indicating the details of an abnormality in the genetics of AT/RT, which is unique to AT/RT type. The INII gene on chromosome 22q11 is involved in the AT/RT. The presence of this gene and the SMARCB1 is discussed. In addition to discussing these important topics, the volume includes presentations of present and future therapies. The volume also explains AT/RT's dissemination to the cerebral fluid, the molecular mechanisms underlying the progression of medulloblastoma, and the importance of gamma knife radiosurgery during multimodality management of medulloblastoma/PNET tumors. Other topics discussed include using magnetic resonance imaging for diagnosing retinoblastoma, and mapping the effects of radiotherapy in low-grade glioma in children. Information on alterations in cell-cycle regulators that are influenced by tumor suppressor genes and oncogenes is detailed. Contributors provide recommendations concerning non-narcotic analgesic routines for children recovering from cranial and spinal surgery. The practical knowledge of frontier-expanding research presented leads this authoritative volume to be a compelling addition to the literature
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Tumors in children -- Diagnosis.
Brain -- Tumors -- Diagnosis.
Brain -- Tumors -- Treatment.
Child.
Neoplasms -- diagnosis.
Neoplasms -- therapy.
Neoplasms, Complex and Mixed.
Neoplasms, Germ Cell and Embryonal.
Form Electronic book
Author Hayat, M. A., 1940-
ISBN 9789400745285 (electronic bk.)
9400745281 (electronic bk.)