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Title Gastrointestinal stromal tumor : research and practice / editors: Yukinori Kurokawa and Yoshito Komatsu
Published Singapore : Springer, 2019
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Description 1 online resource
Contents Intro; Foreword; Preface; Contents; 1: Epidemiology; 1.1 Reported Incidence of GIST and Challenge in Its Ascertainment; 1.1.1 Challenges in Determining the Incidence; 1.1.2 Dataset Used in This Chapter; 1.1.3 Age and Sex of Patients; 1.2 Site of Tumor and Stage Distribution; 1.3 Treatment Modalities; 1.4 Molecular/Genomic Frequencies; 1.5 Survival and Predictors of Recurrence; 1.6 Summary; References; 2: Histology; 2.1 The Definition of GIST; 2.2 Histopathological Features of GIST; 2.3 Extragastrointestinal Stromal Tumor; 2.4 Phenotype-Genotype Correlation in GIST
2.5 SDH-Deficient GIST2.6 Familial GIST; 2.7 Neurofibromatosis Type 1-Related GIST; 2.8 Quadruple Wild-Type GIST; 2.9 Tips for Histopathological Risk Assessment of GIST; 2.10 TKI Treatment-Related Histological Changes in GIST; 2.11 Differential Diagnosis of GIST; 2.11.1 Leiomyoma; 2.11.2 Leiomyosarcoma; 2.11.3 Schwannoma; 2.11.4 Inflammatory Myofibroblastic Tumor; 2.11.5 Desmoid-Type Fibromatosis; 2.11.6 Other Miscellaneous Tumors; References; 3: Genetics; 3.1 Introduction; 3.2 Overview of the Genes Associated with GIST; 3.2.1 c-KIT Gene; 3.2.2 PDGFRA Gene; 3.2.3 NF-1 Gene
3.2.4 SDH Gene Family3.3 Characteristics of GIST by Genotype; 3.3.1 Characteristics of GIST with a c-KIT Mutation; 3.3.2 GIST with PDGFRA Mutations; 3.3.3 GIST with NF1 Mutations; 3.3.4 GIST with SDH Mutations; 3.4 Familial GIST and Its Clinical Features; 3.5 The Relation Between Mutations and Molecular Target Therapy with Imatinib; 3.6 Molecular Mechanisms of Resistance to Imatinib; 3.7 Liquid Biopsy in Gastrointestinal Stromal Tumors; 3.8 Conclusion; References; 4: Diagnostic Imaging of Gastrointestinal Stromal Tumor; 4.1 Introduction; 4.2 Staging
4.2.1 Staging of Gastric GIST4.2.2 Staging of Small Intestinal GIST; 4.3 Primary Tumor; 4.3.1 CT; 4.3.2 MRI; 4.3.3 Positron Emission Tomography/Computed Tomography (PET/CT); 4.4 Metastases; 4.5 Monitoring Tumor Response; 4.6 Conclusion; References; 5: Risk Classification; 5.1 Introduction; 5.2 Risk-Stratification Systems; 5.2.1 National Institutes of Health (NIH) Consensus Criteria; 5.2.2 Armed Forces Institute of Pathology (AFIP) Criteria; 5.2.3 Modified NIH Criteria (Joensuu Risk Criteria); 5.2.4 Contour Maps; 5.2.5 Prognostic Nomograms
5.2.6 C-kit and PDGFRA Gene Mutations5.2.7 Other Pathological Variables and Molecular Markers; 5.3 Discussion; References; 6: Treatment Guidelines; 6.1 Introduction; 6.2 Very Small GISTs (<2 cm); 6.3 Localized Resectable GISTs (Initially Resectable); 6.4 Locally Advanced GISTs (Initially Unresectable); 6.5 Unresectable or Metastatic GISTs; 6.5.1 Initial Approach for Unresectable or Metastatic GISTs; 6.5.2 Second-Line Treatment for Unresectable or Metastatic GISTs; 6.5.3 Third-Line Treatment for Unresectable or Metastatic GISTs; 6.5.4 Other Optional Treatments; References
Summary This book provides a comprehensive and up-to-date overview of gastrointestinal stromal tumors (GISTs). GISTs represent the most common mesenchymal neoplasms arising within the gastrointestinal tract. The causative gene of this disease was originally discovered in Japan by Prof. Seichi Hirota in 1998, and since then numerous important advances - from basic to clinical aspects - have been reported from Japan. Professionals involved in the management of GISTs inevitably cite significant evidence and the state-of-the-art treatments from the Asian region, where has there is and inherently high prevalence of gastrointestinal cancers. Each expert author elucidates the cutting-edge knowledge on pathophysiology, diagnosis, and treatment of GISTs, especially focusing on the highly valuable data from Japan. This attractive collection benefits not only oncologists but also basic researchers, general physicians and surgeons, as well as paramedical staff and medical students who are dealing with GISTs
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (EBSCO, viewed February 25, 2019)
Subject Gastrointestinal system -- Cancer
Gastrointestinal system -- Research
Gastrointestinal system -- Tumors
Gastrointestinal system -- Cancer.
Gastrointestinal system -- Tumors.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Komatsu, Yoshito, editor
Kurokawa, Yukinori, editor
ISBN 9789811332067