| Description |
1 online resource |
| Contents |
Intro -- Sex and Gender Differences in Alzheimer's Disease: The Women's Brain Project -- Copyright -- Dedication -- Contents -- Contributors -- Acknowledgments -- Introduction -- Editors' biography -- Foreword -- Section 1: Sex differences in fundamental neurobiological processes that are relevant to Alzheimer's disease -- Chapter 1 Sex differences in Alzheimer's disease animal models -- Overview of Alzheimer's disease -- AD animal models -- Mutant APP mouse models -- Mouse models with multiple FAD mutations -- Mouse models of tau pathology -- Other AD mutant models -- Evidence for sex differences in AD animal models -- The triple transgenic AD mouse model: 3xTg-AD -- Age-dependent behavioral sex differences -- Sex differences in glucose homeostasis and immune function -- Olfaction and hormonal-related factors -- Lifespan -- APP and PSEN1 transgenic mouse models: TgCRND8, APPswe/PSEN1dE9, APPPS1, and PS2APP/Trem2KO -- ApoE transgenic mouse models: ApoE4/3xTg, 5xFAD/ApoE3, and 5xFAD/ApoE4 -- Tau mouse models: P301S, rTg4510, JNPL3 -- Nontransgenic animals -- Limitations -- Conclusion -- Chapter highlights -- References -- Chapter 2 Sex and sex hormone differences in hippocampal neurogenesis and their relevance to Alzheimer's disease -- Introduction -- Adult neurogenesis in the dentate gyrus -- The function of adult neurogenesis in the hippocampus -- Neurogenesis and aging -- Sex differences in neurogenesis -- Sex differences in neurogenesis in the context of cognitive training -- Alzheimer's disease -- Sex differences in Alzheimer's disease -- Animal models for Alzheimer's disease and sex differences -- Neurogenesis in Alzheimer's disease -- Neurogenesis in models of Alzheimer's disease -- Estrogens and aging -- Estrogens and neurogenesis -- Estrogens and neurogenesis in the context of aging -- Estrogens, aging, and cognition |
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Structural MRI -- Structural MRI sex differences in healthy subjects -- Structural MRI sex differences in dementia -- Conclusion -- Functional MRI -- fMRI sex differences in healthy subjects -- fMRI sex differences in dementia -- Conclusion -- Perfusion SPECT -- Perfusion SPECT sex differences in healthy subjects -- Perfusion SPECT sex differences in dementia -- Conclusion -- Dat Spect -- DAT SPECT sex differences in healthy subjects -- DAT SPECT sex differences in dementia -- Fdg-Pet -- FDG-PET sex differences in healthy subjects -- FDG-PET sex differences in dementia -- Amyloid PET -- Amyloid PET sex differences in healthy subjects -- Amyloid PET sex differences in dementia -- Conclusion -- Emerging PET modalities -- Tau PET sex differences in healthy subjects and dementia -- Neurotransmission PET sex differences in healthy subjects and dementia -- Neuroinflammation PET sex differences in healthy subjects and dementia -- Conclusion -- Chapter highlights -- References -- Chapter 6 Sex and gender differe nces in neuropsychological symptoms for clinical diagnosis of Alzheimer's disease -- Introduction -- Memory -- Introduction -- Sex/gender differences in verbal memory in healthy adults -- Sex/gender differences in verbal memory in mild cognitive impairment -- Sex/gender differences in verbal memory in AD -- Sex/gender differences and rates of verbal memory decline -- Summary -- Language -- Introduction -- Laterality, handedness, and connectivity of the language system -- Semantic dysfunction in neural disorders other than AD -- Critical semantic disruption in AD -- Executive function -- Introduction -- Sex/gender differences in executive function -- Sex/gender differences in cognitive reserve mechanisms -- Conclusion -- Chapter highlights -- Support -- References -- Chapter 7 Sex differences in psychiatric disorders and their implication for dementia |
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Psychiatric disorders matter as modifiable risk factors for dementia over the entire life span -- Major depression: A relevant modifiable risk factor for dementia with sex- and gender-related implications -- Social signal transduction theory of depression: A hypothesis to explain the female's increased vulnerability during child ... -- Late life versus earlier life depression and risk of developing dementia -- Depression or dementia? A key diagnostic challenge in the elderly -- Pharmacotherapy in the elderly: A major challenge with the risk of detrimental polypharmacy -- Antidepressants in dementia -- Polypharmacy -- Behavioral and psychological symptoms of dementia -- Treatment of BPSD: A key challenge in dementia care -- Benzodiazepines in the elderly -- Conclusion -- Chapter highlights -- References -- Chapter 8 Sleep disorders and dementia -- Why do we spend a third of life sleeping? An introduction to sleep and its main characteristics -- Sleep disorders and physiological sleep changes during aging -- Sex- and gender-related differences in sleep and sleep disorders -- Sleep disorders in Alzheimer's disease -- Sleep architecture in Alzheimer's disease -- Treating sleep disorders in Alzheimer's disease -- Sleep disorders and Alzheimer's disease: The caregiver's burden -- Key points -- Insomnia: An independent risk factor for cognitive impairment -- Treating sleep disorders in the elderly -- Key points -- Obstructive sleep apnea syndrome: A risk factor for cognitive impairment and Alzheimer's disease -- Obstructive sleep apnea syndrome and the different clinical pictures in male and female patients -- Obstructive sleep apnea syndrome in relation to cognitive impairment and Alzheimer's disease -- Biomarkers in OSAS and Alzheimer's disease -- Key points |
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REM sleep behavior disorder: A relevant parasomnia and an early clinical biomarker for neurodegenerative diseases -- REM sleep behavior disorder and sex- and gender-related differences -- REM sleep behavior disorder and the risk of clinical manifestation of a neurodegenerative disease -- Sundown syndrome in Alzheimer's disease is associated with RBD -- Key points -- Conclusion -- Chapter highlights -- References -- Chapter 9 Hormones and dementia -- Sex differences are hormone differences -- Hormones and cognition -- Estrogen -- Progesterone -- Testosterone and DHEA -- Menopause and cognition -- Natural menopause -- Surgical menopause -- Observational studies of hormone therapy use -- Interventional HT use -- Hormone therapy and cognition -- Hormone therapy in younger women -- The timing hypothesis -- Side-effect profile -- Hormones and cognition in men -- Gaps in knowledge -- The impact of hormones on known key risk factors for cognitive decline -- Vascular risk and disease (BMI, HT, lipids (APOE4)) -- Diabetes and impaired glucose tolerance -- Metabolic syndrome and inflammation -- Depression -- Sleep -- Midlife to late-life longitudinal prospective studies including hormone, cognitive, and neuropathological biomarkers -- Timing and therapeutic windows -- Information on all types of HT preparation -- Conclusion -- Chapter highlights -- References -- Chapter 10 Sex and gender differences in genetic and lifestyle risk and protective factors for dementia -- Introduction -- APOE allele -- Hormones, menopause, and andropause -- Hormone replacement therapy -- Reproductive history and timing of menopause -- Andropause -- Cardiometabolic risk factors -- Smoking and alcohol consumption -- Physical activity and exercise -- Nutrition -- Sleep disturbances -- Neural reserve and resilience -- Sex and gender dichotomies in cognitive aging research |
| Summary |
Sex and Gender Differences in Alzheimer's Disease: The Women's Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer's disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer's disease families, in the frame of a precision medicine approach to Alzheimer's disease.This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer's disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer's a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer's disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer's disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family. Endorsements/Reviews: "There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer's disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol., PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel-- Provided by publisher |
| Subject |
Alzheimer's disease.
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Brain -- Sex differences
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Women's health services.
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Sex differences.
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Alzheimer Disease
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Sex Characteristics
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Sex differences
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Alzheimer's disease
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Brain -- Sex differences
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Women's health services
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| Form |
Electronic book
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| Author |
Ferretti, Maria Teresa
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Dimech, Annemarie Schumacher
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Santuccione, Antonella Chadha
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| ISBN |
9780128193457 |
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012819345X |
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