| Description |
1 online resource |
| Series |
Targeting oxidative stress in cancer ; 2 |
| Contents |
Intro -- Preface -- Contents -- About the Editor -- Contributors -- Part I: Therapeutic Implications of Natural Compounds -- 1 Elimination of Senescent Cells by Polyphenols and Flavonoids -- Introduction -- Cellular Senescence -- Markers of Cellular Senescence -- Senescence-Associated Mitochondrial Dysfunction (SAMD) -- Senescence-Associated Secretory Phenotype (SASP) -- Bystander Effect -- Therapy-Induced Senescence (TIS) -- TIS Induced by Polyphenols -- Escape From TIS -- Senescent Cells: A Survival Niche Generating a Complex Tumor Environment |
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Importance of TIS by the Example of Radiotherapy-Induced Senescence -- Role of TIS in Other Cancer Treatments -- Polyphenols Inhibiting SASP (Senostatics) -- Apigenin -- Epigallocatechin-3-Gallate (EGCG) -- Resveratrol -- Quercetin -- Polyphenols as Senolytics (Polyphenols Killing Senescent Cells) -- Fisetin -- Quercetin -- Epigallocatechin-3-Gallate (EGCG) -- Curcumin -- Herbal Extracts with Senolytic and Senomorphic Properties -- Extract of the Plant Solidago virgaurea Subsp. alpestris -- Alcoholic Extract of Ajuga taiwanensis -- Pinellia ternata Tuber -- Olive Plant -- Conclusion -- References |
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2 Natural Dietary Alkaloids and Its Synthetic Derivatives as Oxidative Stress-Inducing Agents for Cancer Therapy -- Introduction -- Berberine -- Piperine -- Neferine -- Piperlongumine -- Conclusion -- References -- 3 Natural Therapeutic Strategies for Modulating Oxidative Stress in Cancer -- Introduction -- Oxidative Stress and Carcinogenesis -- Antioxidant Defense Mechanism -- Oxidative Stress and Natural Compounds -- The Role of Antioxidant Potential of Phytochemicals in Oxidative Stress -- Mechanism of Natural Compounds in Combination with Chemotherapy |
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Marine Product with Antioxidative Stress Activity -- Microbial Antioxidative Stress Compounds -- Conclusion -- Future Perspective -- References -- 4 Antioxidant in Cancer -- Introduction -- Reactive Oxygen Species (ROS) -- Reactive Oxygen Species (ROS) in Cancer -- Antioxidants -- Antioxidants Types -- Defense Mechanism of Antioxidant -- Antioxidant: Preventer of Cancer -- Antioxidant: Promoter of Cancer -- Antioxidant: An Achilles ́Heel -- The Antioxidant Conundrum: Friend or Foe -- Conclusion -- References -- 5 Antioxidant Activity of Phytochemicals in Cancer -- Introduction |
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Role of Reactive Oxygen Species (ROS) in Cancer Progression -- ROS and Chemoresistance Development -- Cellular Redox System and Molecular Mechanisms Against ROS -- Phytochemicals and Their Antioxidant Activity in Cancer -- Triphala -- Resveratrol -- Indole-3 Carbinol (I3C) -- Peucedanum Chenur -- Astaxanthin -- Quercetin -- Ellagic Acid -- Caryophyllene Sesquiterpenes -- Phlorotannins -- The Antioxidant/Pro-oxidant Enigma of Cancer Therapy -- Phytochemicals as Immunotherapy Adjuvants -- Conclusion and Future Perspectives -- References |
| Summary |
This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy |
| Notes |
Print version record |
| Subject |
Oxidative stress -- Physiological effect
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Cancer -- Treatment.
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Cancer -- Pathophysiology.
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Cancer -- Pathophysiology
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Cancer -- Treatment
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Estrès oxidatiu.
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Càncer.
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Fisiologia patològica.
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| Genre/Form |
handbooks.
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Handbooks and manuals.
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Guides et manuels.
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Llibres electrònics.
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| Form |
Electronic book
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| Author |
Chakraborti, Sajal, editor
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| ISBN |
9789811654220 |
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9811654220 |
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