Title Pain therapeutics : current and future treatment paradigms / [edited by] Charlotte Allerton, David Fox

Published [Cambridge] : Royal Society of Chemistry, 2013

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Description 1 online resource Series RSC drug discovery ; volume 35 RSC drug discovery series ; v. 35. Contents Fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; _s_h_o_w_10_; _s_h_o_w_223_; _s_h_o_w_260_; _s_h_o_w_312_; _s_h_o_w_330_; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig5; fig5; fig6; fig6; fig5; fig5; fig6 Fig6fig5; fig5; fig6; fig6; fig5; fig5; fig6; fig6; fig5; fig5; fig6; fig6; fig5; fig5; fig7; fig7; fig7; fig7; fig7; fig7; fig7; fig7; fig7; fig7; fig8; fig8; fig8; fig8; fig8; fig8; fig8; fig8; fig8; fig8; fig9; fig9; fig10; fig10; fig9; fig9; fig10; fig10; fig9; fig9; fig10; fig10; fig9; fig9; fig10; fig10; fig9; fig9; fig11; fig11; fig11; fig11; fig11; fig11; fig11; fig11; fig12; fig12; fig12; fig12; fig12; fig12; fig12; fig12; fig13; fig13; fig13; fig13; fig13; fig13; fig14; fig14; fig14; fig14; fig14; fig14; fig15; fig15; fig16; fig16; fig15; fig15; fig16; fig16; fig15; fig15; fig16 Fig16fig17; fig17; fig17; fig17; fig17; fig17; fig18; fig18; fig19; fig19; fig18; fig18; fig19; fig19; fig18; fig18; fig19; fig19; fig20; fig20; fig20; fig20; _s_h_o_w_65_; _s_h_o_w_77_; fig21; fig21; _s_h_o_w_335_; _s_h_o_w_339_ Summary This book presents a contemporary review of the field of Pain Therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets from pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific changes in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally the book covers the discovery and development stories for two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product Notes English Publisher supplied information Subject Analgesics. Diseases. Senses and sensation. Neurologic manifestations of general diseases. Psychophysiology. Neurotransmitter receptors. Nervous system -- Diseases. Cell receptors. Membrane proteins. Proteins. Pain. Opioids -- Receptors. Anti-inflammatory agents. Neurotransmitters. Nervous System Physiological Phenomena Disease Therapeutic Uses Sensory System Agents Sensation Receptors, G-Protein-Coupled Neurologic Manifestations Receptors, Neuropeptide Signs and Symptoms Molecular Mechanisms of Pharmacological Action Central Nervous System Agents Physiological Effects of Drugs Pharmacologic Actions Receptors, Peptide Psychophysiology Receptors, Neurotransmitter Pathological Conditions, Signs and Symptoms Peripheral Nervous System Agents Nervous System Diseases Receptors, Cell Surface Chemical Actions and Uses Psychological Phenomena and Processes Membrane Proteins Proteins Chemicals and Drugs Psychiatry and Psychology Musculoskeletal and Neural Physiological Phenomena Amino Acids, Peptides, and Proteins Phenomena and Processes Pain Receptors, Opioid Anti-Inflammatory Agents Neurotransmitter Agents Analgesics protein. Chemistry. MEDICAL -- Pharmacology. Senses and sensation Psychophysiology Proteins Pain Opioids -- Receptors Neurotransmitters Neurotransmitter receptors Neurologic manifestations of general diseases Nervous system -- Diseases Membrane proteins Diseases Cell receptors Anti-inflammatory agents Analgesics Form Electronic book Author Allerton, Charlotte, editor Fox, David, editor ISBN 9781849737715 1849737711

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