Title Haschek and Rousseaux's handbook of toxicologic pathology. Volume I, Principles and practice of toxicologic pathology / editors, Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon ; associate editors, Stacey L. Fossey, John H. Vahle ; illustrations editor, Beth W. Mahler

Edition Fourth edition Published London : Academic Press, an imprint of Elsevier, [2022] ©2022

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Description 1 online resource (xxvi, 1125 pages) : illustrations (chiefly color) Contents Toxicologic pathology: an introduction -- Biochemical and molecular basis of toxicity -- ADME principles in small molecule drug discovery and development: an industrial perspective -- Biotherapeutics ADME and PK/PD principles -- Principles of pharmacodynamics and toxicodynamics -- The role of pathology in evaluation of reproductive, developmental, and juvenile toxicity -- Carcinogenesis: mechanisms and evaluation -- Basic approaches in anatomic toxicologic pathology -- Clinical pathology in nonclinical toxicity testing -- Special techniques in toxicologic pathology -- Digital pathology and tissue image analysis -- In vivo small animal imaging: a comparison to gross and histopathologic observations in animal models -- Biomarkers: discovery, qualification, and application -- Toxicogenomics: a primer for toxicologic pathologists -- Experimental design and statistical analysis for toxicologic pathologists -- Animal models in toxicologic research: rodents -- Animal models in toxicologic research: rabbit -- Animal models in toxicologic research: dog -- Animal models in toxicologic research: pig -- Animal models in toxicologic research: nonhuman primate -- Animal models in toxicologic research: nonmammalian -- Genetically engineered animal models in toxicologic research -- Alternative models in biomedical research: in silico, in vitro, ex vivo, and nontraditional in vivo approaches -- Nomenclature and diagnostic resources in anatomic toxicologic pathology -- Pathology peer review -- Pathology and GLPs, quality control, and quality assurance -- Practices to optimize generation, interpretation, and reporting of pathology data from toxicity studies -- Issues in laboratory animal science that impact toxicologic pathology Bibliography Includes bibliographical references Notes Online resource; title from digital title page (Elsevier ClinicalKey, viewed on February 3, 2022) Subject Toxicology -- Handbooks, manuals, etc Physiology, Pathological -- Handbooks, manuals, etc Veterinary toxicology -- Handbooks, manuals, etc Toxicology. Poisoning -- pathology Toxicology toxicology. Physiology, Pathological Toxicology Veterinary toxicology Genre/Form handbooks. Handbooks and manuals Handbooks and manuals. Guides et manuels. Form Electronic book Author Haschek, Wanda M., editor. Rousseaux, Colin George, 1954- editor. Wallig, Matthew A., editor. Bolon, Brad, editor. ISBN 9780128218297 0128218290

Other Titles Principles and practice of toxicologic pathology

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