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Title Predictive, preventive, and personalised medicine : from bench to bedside / Halina Podbielska, Marko Kapalla, editors
Published Cham, Switzerland : Springer, [2023]

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Description 1 online resource (352 p.)
Series Advances in Predictive, Preventive and Personalised Medicine ; volume 17
Advances in predictive, preventive and personalised medicine ; v.17.
Contents Intro -- Preface -- Contents -- About the Editors -- PPPM Innovation in Primary, Secondary and Tertiary Care -- 1 Health-to-Disease Transition in Focus of Advanced Bio/Medical Sciences and Healthcare Services -- 2 A Holistic Approach by 3P Medicine Is the Clue -- 3 Technological Innovation -- 4 Conclusion -- References -- Suboptimal Health Innovation: From Bench to Bedside -- 1 Introduction -- 2 Suboptimal Health Status -- 3 Diagnostic Tools for SHS -- 3.1 Subjective Measure -- 3.2 Objective Measurements Enhance the Reliability of SHSQ-25
4 Paradigm Shift from Reactive to Predictive, Preventive, and Personalized Medicine -- 5 Conclusion and Recommendations -- Appendix 1: SHSQ-25 -- English Version -- Chinese Version -- Russian Version -- Korean Version -- References -- What Is the Routine Mitochondrial Health Check-Up Good For? A Holistic Approach in the Framework of 3P Medicine -- 1 By Regulating Whole-Body Physiological Functions, Mitochondria Are at the "Forefront" of Holistic PPPM Approach -- 1.1 Mitochondrial Dynamics and Circadian Rhythmicity -- 1.2 Shift Work -- 1.3 Chronic Stress, Fatigue and Mitochondrial Burnout
2 Microvascular Deficits and Silent Lacunar Brain Lesions in Flammer Syndrome: A Case Presentation for Implementing PPPM Strategies -- 3 Compromised Mitochondrial Health in Critical Illnesses: Prominent Examples -- 3.1 Mitochondrial Dysfunction in the Ageing-Related Metabolic Disorders -- 3.2 Female and Male Reproductive Health -- 3.3 Pathologic Pregnancy -- 3.4 Connective Tissue Dysregulation -- 3.5 Atrial Fibrillation (AF) -- 3.6 Ischemic Stroke -- 3.7 Skin Disorders -- 3.7.1 Atopic Dermatitis (AD, Also Atopic Eczema/Neurodermitis) -- 3.8 Impaired Wound Healing -- 3.9 Cancers
3.10 Sleep Disorders -- 3.11 Psychiatric Disorders -- 3.12 Endocrine Disorders -- 3.13 Kidney Disease -- 3.14 Liver Disorders -- 3.15 Eye Disorders -- 3.15.1 Retinal Microvascular Endothelial Cells Dysfunction -- 3.15.2 Myopia -- 3.15.3 Glaucoma -- 3.15.4 Diabetic Retinopathy -- 3.15.5 Early Cataract -- 3.16 Neurodegeneration -- 3.17 Musculoskeletal Degenerative Disorders -- 3.18 Respiratory Diseases -- 3.19 Long COVID -- 4 Conclusions and Outlook in the Framework of 3P Medicine -- References
Prehabilitation as an Integral Procedure in Predictive, Preventive, and Personalized Medicine and Modern and Effective Healthcare -- 1 Introduction -- 1.1 History of Prehabilitation -- 2 Prehabilitation -- 2.1 Multimodal Approach of Prehabilitation -- 2.1.1 The Reason for Multimodal Approach in Prehabilitation -- 2.2 Exercise and Physical Activity (Rehabilitation) as Element of Prehabilitation -- 2.2.1 Patient Examination and Setting Up Training in Terms of Prehabilitation -- 2.2.2 6-Minute Walk Test -- 2.2.3 Chair Stand Test -- 2.2.4 Timed Up-and-Go Test (TUG)
Summary This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine
Bibliography Includes bibliographical references
Notes 2.2.5 SF36 Quality of Life Questionnaire
Description based on online resource; title from digital title page (viewed on November 29, 2023)
Subject Precision medicine.
Medicine, Preventive.
Precision Medicine
Preventive Medicine
Medicine, Preventive.
Precision medicine.
Form Electronic book
Author Podbielska, Halina.
Kapalla, Marko
ISBN 3031348842
9783031348846